Kikkoman Corporation

Tadaomi Kawashima

Noriko Tsuji

Daisuke Kaneko

Akemi Kosaka

Ikuko Masuda

Naho Ikari

Hiroshi Kawamoto

An object of the present invention is to provide a method for efficiently obtaining a lactic acid bacterium that is made to contain a large amount of double-stranded RNA; and a lactic acid bacterium having a high double-stranded RNA content obtained by the method. The object is achieved by: (1) a method for producing a double-stranded RNA-containing lactic acid bacterium, including a step of culturing a lactic acid bacterium under at least one condition of an aeration condition and a low-temperature condition lower than an optimum temperature, thereby obtaining the double-stranded RNA-containing lactic acid bacterium; (2) a double-stranded RNA-containing lactic acid bacterium, in which the content of double-stranded RNA is 2.0 times or more as compared with the content of double-stranded RNA when a bacterium of the same strain is cultured for the same culture time under an optimum temperature and non-aeration condition; or the like.

Method for producing double-stranded RNA-rich lactic acid bacterium, and said lactic acid bacterium

An immunoregulator that is safe and efficiently incorporated into cells along with a production process thereof are provided. Double-stranded RNA derived from lactic acid bacteria, an immunoregulator having for an active ingredient thereof double-stranded RNA derived from lactic acid bacteria, and a process for producing double-stranded RNA derived from lactic acid bacteria are provided. Bacteria cells of a strains of lactic acid bacteria such as genus, genus, genus, genusor genusare able to produce double-stranded RNA having immunoregulatory action therein.

Lactic acid bacteria-derived double-stranded RNA

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Noda, Japan

Tadaomi Kawashima