Cell-medicine, Inc.

National Institute of Advanced Industrial Science and Technology

Riken Corporation

University of Tsukuba

Nihon Parkerizing Co., Ltd.

The Institute of Physical and Chemical Research

Kaneka Corporation

Tadao Ohno

Kam W Leong

Yasuyoshi Ueda

Takahiro Ueda

Shiro Kitamura

Shu Qin Liu

Takeshi Todoroki

Eiji Uchimura

Bao Gang Peng

Mayu Yasunaga

Yu Sogo

Fumiko Kobayashi

Atsuo Ito

A medical instrument in which an inorganic salt solid such as apatite into which a peptide hormone or the like is embedded is placed so that a metal or the like is coated therewith, in which the inorganic salt solid is provided by controlled delay co-precipitation or the like in an unstable supersaturated calcium phosphate solution, and the medical instrument is exposed to ionizing radiation at a dose sufficient for sterilization.

Inorganic salt-protein composite medical instrument

A complex comprising a carrier containing a plasma-derived protein or serum-derived protein solidified by denaturation coagulation, and a protein having a peroxidase-like activity and carried by the carrier, which has such high effectiveness that it can strongly stimulate an antigen-presenting cell, and can be used as a highly safe immunostimulant with reduced toxicity to living bodies.

Immunostimulant

An immunoadjuvant comprising one kind or two or more kinds of immunostimulating substances carried separately by two or more kinds of different microparticle immunostimulating substance carriers, and comprising at least a combination of (a) an inorganic substance such as microparticle calcium phosphate having a size phagocytizable by cells, and (b) precipitates of a soluble protein and a mucopolysaccharide formed by coacervation as the microparticle immunostimulating substance carriers, which is highly safe and can exhibit potent immunoadjuvant activity.

Immunoadjuvant

A tumor vaccine which comprises a microparticle or a lysate prepared from a solidified tumor material selected from the group consisting of a tumor tissue, a tumor cell, and a component thereof, and at least one cytokine and/or cytokine-inducing agent (e.g., a granulocyte-macrophage-colony stimulating factor and/or interleukin-2 and the like), and optionally an adjuvant. The vaccine can be easily prepared and widely applied for prevention of recurrence, inhibition of metastasis and therapeutic treatment regardless of a type of a tumor, and has excellent antitumor effect.

Tumor vaccines

A process for an induction culture of a cytotoxic T lymphocyte having cell killing activities against a tumor cell which comprises the step of coculturing a tumor tissue containing said tumor cell and a lymphocyte of autologous peripheral blood obtained from a subject from which the tumor tissue is derived. The process is convenient since no separation and pure culture of tumor cells is required. The resulting cytotoxic T lymphocyte cells are useful for clinical treatments of tumors, e.g. adoptive immunotherapies.

Process for induction culture of cytotoxic T lymphocytes having killing

Growing community of inventors

Ibaraki, Japan

Tadao Ohno