Yamanouchi Pharmaceutical Company Ltd.

Other

Tadao Kojima

Minoru Okada

Isao Ohata

Noboru Sato

Shunji Kageyama

Toichi Takenaka

Kazuharu Tamazawa

Yasuo Isomura

Yukiyasu Murakami

Hideki Arima

Kiyoshi Takanobu

Takashi Fujikura

Masuo Murakami

Kozo Takahashi

Kunihiro Niigata

Masaru Iwanami

Shinji Usuda

Shiro Tachikawa

Yoshihisa Nozaki

Soichi Kagami

Yuji Kawashima

A process is provided for producing diastereoisomer A or a pharmaceutically acceptable acid addition salt of 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-(1-benzylpyrrolidin-3-yl) ester 5-methyl ester which comprises subjecting a mixture of diastereoisomers A and B of 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-(1-benzylpyrrolidin-3-yl) ester 5-methyl ester to column chromatography using silica gel as a carrier and a mixture of ethyl acetate and acetic acid as an eluant, and then separating the acetate of diastereoisomer A from the eluate, or treating the acetate with a base, or further treating the resulting diastereoisomer A with a pharmaceutically acceptable acid.

Dihydropyridine-3, 5-dicarboxylic acid ester derivatives

A dextro-rotatory optical isomer of diastereoisomer A of (.+-.)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-(1-benzylpyrrolidin-3-yl)ester 5-methyl ester is provided having the formula ##STR1## and wherein the melting point of the hydrochloride of the dextro-rotatory optical isomer is 223.degree. to 230.degree. C. (decomp.), or a pharmaceutically acceptable acid addition salt thereof.

Dihydropyridine-3,5-dicarboxylic acid ester derivatives

The diastereoisomer A of a dihydropyridine-3,5-dicarboxylic acid ester derivative is provided as well as its pharmaceutically acceptable acid addition salts. The invention further discloses a process for producing the compounds and their use as medicaments in imparting vasodilating activity.

Thiazolyl phenoxy derivatives are provided as well as pharmaceutical compositions containing such derivatives. The compositions are useful for lowering lipid activity in a subject and accordingly useful for reducing cholesterol and triglycerides.

Certain thiazol-4-yl-phenoxy derivatives having lipid lowering properties

The present invention relates to novel phenoxy derivatives represented by the formula (I): ##STR1## wherein: A is an imidazolyl group, a pyridyl group, a pyridyloxy group, an oxo-substituted chromenyloxy group, a lower alkyl group, an amino group which may be substituted with a phenyl group or a lower alkyl group, or a carbamoyl group substituted with a cyclohexylamino group or an imidazolylalkyl group;

Certain pyridinyl or imidazolinyl-4-thiazolyl-phenoxy alkanoic acid

The present invention relates to novel phenoxy derivatives represented by the formula (I): ##STR1## wherein: A is an imidazolyl group, a pyridyl group, a pyridyloxy group,

Certain pyridyl or imidazol-1-yl-alkyleneoxy-(or

Imidazolyl phenoxy derivatives are provided as well as pharmaceutical compositions containing such derivatives. The compositions useful for lowering lipid activity in a subject and accordingly useful for reducing cholesterol and triglycerides.

Imidazolyl phenoxy compounds and method of use

Novel coumarin compounds of the formula ##STR1## wherein R.sup.1 represents an imidazolyl group or a pyridyloxy group which may be substituted by lower alkyl group(s); R.sub.2 represents a hydrogen atom or a lower alkyl group; and m represents an integer of 1 to 6; and the salts thereof, which inhibit platelets aggregation.

Coumarins with imidazolyl group or pyridyloxy group having plateletes

1,4-Dihydropyridine-3,5-dicarboxylic acid ester derivatives shown by the formula ##STR1## wherein R represents a lower alkyl group and R' represents a hydrogen atom, a lower alkyl group or an aralkyl group, and the therapeutically non-toxic salts thereof. These compounds possess a vasodilative activity and an antihypertensive activity.

1,4-Dihydropyridine-3,5-dicarboxylic acid ester derivatives

Process for producing 7.beta.-amino-7.alpha.-methoxycephalosporins without the epimerization or formation of the corresponding 7.alpha.-amino-7.beta.-methoxy isomers by deacylating cephalosporin derivatives having 7.beta.-acylamino-7.alpha.-methoxy group.

Process for producing 7.beta.-amino-7.alpha.-methoxycephalosporins

2-(Indenyloxymethyl) morpholine derivatives are disclosed. These derivatives are excellent in methamphetamine stereotyped increasing and antireserpine activities which are useful as antidepression agents.

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Saitama, Japan

Tadao Kojima