Toyo Jozo Kabushiki Kaisha

Tadanori Morikawa

Toshiharu Noda

Eisuke Munekata

Susumu Watanabe

Masaru Otani

Tetsuo Matsuda

Shumpei Sakakibara

Shunpei Sakakibara

Terutoshi Kimura

Hirose Yamauchi

Yasuo Nakagawa

Tosio Meguro

Shuichi Kitazawa

Polypeptides of the formula ##STR1## wherein A.sub.1 is Ser or Gly, A.sub.7 is Val or Met, A.sub.10 is Lys or Thr, A.sub.11 is Leu or Tyr, A.sub.12 is Ser or Thr, A.sub.14 is Glu or Asp, A.sub.15 is Leu or Phe, A.sub.16 is His or Asn, A.sub.18 is Leu or Phe, A.sub.19 is Gln or His, A.sub.21 is Tyr or Phe, A.sub.23 is Arg or Gln, A.sub.25 is Asp or Asn or Ala, A.sub.26 is Val or Thr or Ile, A.sub.28 is Ala or Ser or Val, and A.sub.30 is Thr or Val or Ala, and pharmaceutically acceptable acid addition salts and complexes, have serum calcium reducing activity.

Polypeptides and process for producing the same

A polypeptide having calcitonin activity of the formula ##EQU1## and the salts thereof with pharmaceutically acceptable acids.

EEL calcitonin

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Takatsuki, Japan

Tadanori Morikawa