Fuji Yakuhin Kogyo Kabushiki Kaisha

Daiichi Fine Chemical Co., Ltd.

Nippon Mining Co., Ltd.

Japan Energy Corporation

Tadanori Morikawa

Shinjiro Odake

Sakayu Shimizu

Michihiko Kataoka

Keiji Sakamoto

Shinji Kita

Satoru Misawa

Kyoichi Kobashi

Kazuya Tsuzaki

Akiko Sukesada

Masaharu Nakano

Tomoko Hongo

Eriko Nukui

Ryo Muramatsu

Koichi Wada

Yasuo Morita

Hajime Ito

Eiko Suda

Katsuhiro Igeta

Tetsunori Fujisawa

Yutaka Nagai

Junko Yasuda

Masami Obata

Toru Okayama

Junko Fujisawa

A protein, which is an aminoketone asymmetric reductase, having an effect of producing d-pseudoephedrine by acting on 1-2-methylaminopropiophenone, and having the following physiochemical properties:

Aminoketone asymmetric reductase and nucleic acid thereof

Process for the production of optically active &bgr;-amino alcohols

New compounds of general formulae (III), (IV) and (V).

Highly water-soluble metalloproteinase inhibitors

The present invention relates to hirudin variants having high anti-thrombin and anti-platelet activity, methods for producing them, and anti-coagulants having said variants as active ingredients. Hirudin variants shown in formula (I) having tyrosine residues or having their hydroxyl group sulfated. Methods for producing hirudin variants by sulfating hydroxyl group of said tyrosine residues, and anti-coagulants having hirudin variants shown in formula (I) as active ingredients.

Anticoagulant hirudin variants and methods for their production

Hydroxamic acid tetrapeptide derivatives

Growing community of inventors

Takaoka, Japan

Tadanori Morikawa