Daiichi Seiyaku Co., Ltd.

Tadamasa Hirayama

Ichiro Azuma

Tetsuo Shiba

Yuichi Yamamura

Shoichi Kusumoto

Tsuneo Kusama

Masahiro Kamada

Hideaki Tsurumi

Muramyldipeptide derivatives of the formula: ##STR1## wherein Y represents a mycoloyl group or a synthetic higher acyl group having total carbon number of C30-C90 and having at least a branched chain of long alkyl group on the .alpha.-position thereof,

Muramyldipeptide derivatives and process for the preparation thereof

A process for preparing a 2-halopyrimidine derivative represented by the formula: ##SPC1## Wherein R.sup.2 represents a hydrogen atom, a halogen atom, a lower alkyl group, an aryl group, and an amino group and R.sup.4 represents a lower alkyl group and X represents a halogen atom, which comprises reacting cyanoacetimidate derivative represented by the formula: ##EQU1## wherein R.sup.2 and R.sup.4 represent the same as above and M represents a mineral acid residue with cyanamide, to produce an N-cyanocyanoacetimidate ##EQU2## represented by the formula: WHEREIN R.sup.2 and R.sup.4 represent the same as above, and thereafter reacting said N-cyanocyanoacetimidate with a hydrogen halide.

2-Halopyrimidine derivatives and a method for their preparation

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Tokyo, Japan

Tadamasa Hirayama