Japan Science and Technology Agency

Tadamasa Arai

Motomu Kanai

Yohei Soma

Daisuke Sasaki

Yuki Kobayashi

Takushi Araya

Provided is a novel compound which has an excellent A&#x3b2; aggregation inhibitory effect and is useful as a pharmaceutical. An amide compound represented by the formula (1) or a salt thereof, wherein Z represents CH or N; A and B are the same or different and each represents &#x2014;CH&#x2014;, &#x2014;O&#x2014;, &#x2014;S&#x2014;, or &#x2014;NH&#x2014;; Rand Rare the same or different and each represents a branched alkyl group, a branched alkenyl group, an optionally substituted aromatic hydrocarbon group, an optionally substituted aralkyl group, an optionally substituted cycloalkyl group, or an optionally substituted aromatic heterocyclic group; and Rrepresents a branched alkyl group, a branched alkenyl group, an optionally substituted cycloalkyl group, or an optionally substituted aralkyl group. 

Amide compound and pharmaceutical comprising same

A cyclic peptide or a salt thereof of formula (1): X-Leu-Val-Y-Y(1), where X is Lys, Arg, His, Ala, Gly, Ser, or Thr; and Yand Y, which are identical to or different from each other, each represent a group represented by formula (2): where Arrepresents an aromatic hydrocarbon group or an aromatic heterocyclic group; Rrepresents a hydrogen atom, an alkyl group, a cycloalkyl group, a haloalkyl group, an aromatic hydrocarbon group, or an aromatic heterocyclic group; and n is an integer from 0 to 2. In the cyclic peptide has an &#x3b1;-amino group at the amino terminus of the amino acid sequence which is linked, via a peptide bond, to the carboxyl group at the carboxyl terminus of the amino acid sequence.

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Fujisawa, Japan

Tadamasa Arai