Jsr Corporation

Shiseido Company, Limited

Other

Japan Science and Technology Agency

Toudai Tlo, Ltd.

Tadahito Takahashi

Kazunori Kataoka

Yukio Nagasaki

Miki Kato

Hiroshi Kobayashi

Paul F Goetinck

Toshihiko Hibino

Masami Nakamae

Fumiko Aboshi

Tomoko Jomura

Yoshinori Katsuyama

Takehiko Ishii

Michihiro Yamaguchi

Toshio Yanaki

Hidenori Otsuka

Peter C Baciu

Izumi Horii

Yoko Nagasawa

Katsumi Uchida

A substrate surface on which either a substance to detect analyte or an analyte per se is immobilized, which surface is formed by a treatment of substrate surface with a liquid which contains uncrosslinked polymer based on polyethylene glycol chain segment, said treatment conducted either simultaneously with the immobilization of said substance or analyte or after said substance or analyte has been immobilized on said surface. The non-specific adsorption of impurity protein or the like which is co-existent in sample for assay is significantly restrained.

Surface of substrate onto which non-specific adsorption is restrained

Surface of base material being inhibited in non-specific adsorption

This invention provides a method to detect analyte which comprises preparing fine particles which have a chargeable group in their core and a hydrophilic polymer chain in their shell; obtaining an agglutinated matter by forming a biologically specific bond between a specific residue on the surface of fine particles and analyte, and by simultaneously forming a bond by the electrostatic interaction between impure protein and said particles; and subsequently cleaving only the latter bond by raising ionic intensity. Thus, this invention provides a method to detect analyte with rapidity and high sensitivity with use of agglutination reaction.

Method of high-speed detection for biological analyte

A surface on which adsorption of protein (e.g., BSA) is markedly suppressed is provided, by contacting solutions of polymers whose chief component is poly(ethylene oxide) having binding sites to sensor surfaces with biosensor surfaces plural times to link the polymers.

Brush-like structured surface of poly(ethylene oxide) having elevated density

A method of modulating cell proliferation or apoptosis comprising modulating psoriastatin activity.

Two novel genes from psoriatic epidermis: psoriastatin type I and psoriastatin type II

Purified uPA peptides having, mitogenic activity and containing as few as six amino acids of the EGF-like domain of uPA.

Urokinase plasminogen activator fragments

A complex material of a hydrophilic polymer-silicate mineral comprising a carboxyl group containing hydrophilic polymer and a water swellable silicate mineral, and having a new absorption spectrum not existing in both starting materials in the IR-ray absorption spectrum within the range of 1000 to 1300 cm.sup.-1, and pharmaceutical and cosmetic compositions comprising same.

Hydrophilic polymer-silicate mineral complex material and use thereof

Growing community of inventors

Yokohama, Japan

Tadahito Takahashi