Tanabe Seiyaku Company, Limited

Tadahiro Matsushita

Tameo Iwasaki

Kazuhiko Kondo

Totaro Yamaguchi

Hiroshi Horikawa

Akira Nakanishi

Tetsuo Onuki

Tadahiro Oshida

The present invention discloses a protein that possesses an ability to inhibit bacterial DNA gyrase activity (DNA Gyrase-inhibiting protein; DGI); a host cell transformed by a replicable expression vector comprising a DNA that encodes DGI; a process for preparing DGI comprising culturing the same; a method for identifying a medical compound comprising assaying the action of modulating the DNA gyrase-inhibiting activity of DGI; and a method for identifying a medical compound comprising assaying the action of modulating the expression of a DGI-encoding gene.

DNA gyrase-inhibiting proteins

A mercaptan compound of the formula ##STR1## wherein R.sup.3 is a hydrogen atom or a lower alkyl group, or a salt thereof.

Mercaptan compound

1-Methylcarbapenem derivatives of the formula: ##STR1## wherein R.sup.1 is hydrogen atom or a hydroxy-protecting group, R.sup.2 is hydrogen atom or an ester residue, R.sup.3 is hydrogen atom or a lower alkyl group, or salts thereof, which have excellent antimicrobial activities and are useful as an antimicrobial drug.

1-Methylcarbapenem derivatives and process for preparation thereof

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Matsudo, Japan

Tadahiro Matsushita