Teikoku Seiyaku Kabushiki Kaisha

Nippon Kayaku Kabushiki Kaisha

Kaken Pharmaceutical Company, Ltd.

Tadafumi Mizobuchi

Yukio Aouda

Seiichi Sakoh

Yasuyoshi Muguruma

Akihito Ohji

Taiichiro Iwakura

A sheet-shaped adhesive preparation comprising an adhesive layer containing as essential components a carboxyvinyl polymer, a water-insoluble methacrylic copolymer, a polyhydric alcohol and a pharmaceutically active agent, and a water-impermeable and water-insoluble carrier layer containing as essential components a pharmaceutically acceptable water-insoluble, film-forming high molecular weight compound and a plasticizer, which can adhere within the oral cavity for a longer period of time and can release the active agent and hence is useful as a sustained release preparation for the oral cavity.

Sheet-shaped adhesive preparation applicable to oral cavity

A sheet-like preparation comprising a composition comprising (a) a drug, (b) gelatin or agar, (c) gluten, (d) a carboxyvinyl polymer, (e) a polyhydriic alcohol, (f) a gum and (g) wax as its essential constituents, and water in an amount of 0 to 30 w/w % based on the total weight of the essential constituents, and a sheet-like support which supports thereon said composition. The sheet-like preparation of this invention is useful, for example, as a preparation for oral cavity administration.

Sheet-like preparation

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Kagawa, Japan

Tadafumi Mizobuchi