Otsuka Pharmaceutical Company, Limited

Tadaaki Otani

Hirofumi Sasaki

Naoto Utsumi

Hidetsugu Tsubouchi

Hideaki Kuroda

Shigekazu Fujita

Noriaki Takemura

Fumitaka Goto

Takeshi Hasegawa

Takuya Shitsuta

The present invention relates to a 1-substituted-4-nitroimidazole compound represented by the general formula (1) or a salt thereof, (wherein R is a hydrogen atom, a lower alkoxy group-substituted lower alkyl group, a phenyl-lower alkoxy group-substituted lower alkyl group, a cyano-substituted lower alkyl group, a phenyl-lower alkyl group which may have lower alkoxy groups as the substituents in the phenyl ring or a group of the formula &#x2014;CHR; X is a halogen atom or a group of the formula &#x2014;S(O)n-R) and method for preparing the same. The compound of the formula (1) is a useful compound as an intermediate for synthesis of various pharmaceutical and agricultural chemicals, particularly, as intermediates for antitubercular agents.

1-substituted-4-nitroimidazole compound and method for preparing the same

The present invention relates to a 1-substituted-4-nitroimidazole compound represented by the general formula (1) or a salt thereof, (wherein R is a hydrogen atom, a lower alkoxy group-substituted lower alkyl group, a phenyl-lower alkoxy group-substituted lower alkyl group, a cyano-substituted lower alkyl group, a phenyl-lower alkyl group which may have lower alkoxy groups as the substituents in the phenyl ring or a group of the formula &#x2014;CHR; X is a halogen atom or a group of the formula &#x2014;S(O)n&#x2014;R) and method for preparing the same. The compound of the formula (1) is a useful compound as an intermediate for synthesis of various pharmaceutical and agricultural chemicals, particularly, as intermediates for antitubercular agents.

1-substituted-4-nitroimidazole compound and process for producing the same

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Matsushige, Japan

Tadaaki Otani