Mediventures Inc.

Mdv Technologies, Inc.

Distek, Inc.

Tacey X Viegas

Lorraine E Reeve

Raymond L Henry

Robert S Levinson

Michael Cai

Gerald Brinker

Wen Zhang

Lin Cheng

Jennifer Riggs-Sauthier

For intrinsic dissolution testing, a drug pellet (i.e., the dissolution test sample) is retained within a cylindrical recess in a sample holder that is placed at the bottom of a dissolution vessel containing an appropriate dissolution medium with the sample holder oriented with the drug pellet facing up. During the testing cycle, the dissolution medium may be stirred, e.g., using a conventional USP 2 rotating paddle, while the sample holder (and drug pellet) remain stationary at the bottom of the vessel. The orientation of the drug pellet during testing (i.e., facing up) decreases the likelihood of retention of air bubbles formed at the surface of the drug pellet (which bubbles could otherwise decrease the effective dissolution rate), thereby providing more accurate and consistent intrinsic dissolution test results.

Intrinsic dissolution apparatus with stationary sample holder

Balanced pH, thermo-irreversible gels are ideal vehicles for drug delivery to a body cavity of a mammal. The gels contain a mixture of a polyoxyalkylene block copolymer or polyether together with an ionic polysaccharide which is thermo-irreversibly gelled in the presence of a counter-ion.

Body cavity drug delivery with thermo-irreversible polyoxyalkylene and ionic polysaccharide gels

Balanced pH, hyperosmotic, hypoosmotic, or isoosmotic gels are ideal vehicles for drug delivery. They are especially suited for topical body cavity or injection application of drugs or diagnostic agents; for drug or diagnostic agent delivery to the eye of a mammal; as protective corneal shields; or as ablatable corneal masks useful in laser reprofiling of the cornea. The compositions without the addition of a drug or diagnostic agent are useful as medical devices, for instance, in separating surgically or otherwise injured tissue as a means of preventing adhesions.

Medical uses of in situ formed gels

Balanced pH, thermo-irreversible gels comprising a polyoxyalkylene compound and an ionic polysaccharide are ideal materials for the formation of a protective contact lens over the cornea of the eye of a mammal.

Thermal irreversible gel corneal contact lens formed in situ

Compositions based upon aqueous gels for medical application, comprising polyoxyalkylene copolymers. Such gels which are isotonic, iso-osmotic, pH balanced, thermo-reversible gels are ideal vehicles for drug or diagnostic agent delivery.

Method of making thermoreversible polyoxyalkylene gels

Thermo-irreversible gel corneal contact lens formed in situ

Body cavity drug delivery with thermo-irreversible polyoxyalkylene and

Isotonic, iso-osmotic, pH balanced thermoreversible gels are ideal medical devices or vehicles for drug injection into the body of a mammal. The osmolality in the gel state can be calculated by assuming that a polyoxyalkylene block copolymer or polyether present in said gel does not contribute to the osmolality in the gel state, although it does contribute to the osmolality in the liquid state.

Drug delivery by injection with thermoreversible gels containing

Aqueous gel drug delivery compositions and medical devices, useful for treating an eye condition, having hyperosmotic, iso-osmotic or hypo-osmotic characteristics in the gel state, are obtained by calculating the osmolality required in the liquid state to reach a desired osmotic force in the gelled state by assuming that a polyoxyalkylene block copolymer does not contribute to the osmolality in the gel state.

Ophthalmic drug delivery with thermoreversible polyoxyalkylene gels

Iso-osmotic, hyperosmotic, or hypo-osmotic, pH balanced, thermoreversible gels are ideal medical devices or vehicles for drug delivery to the skin of a mammal. The osmolality in the gel state can be calculated by assuming that a polyoxyalkylene block copolymer or polyether present in said gel does not contribute to the osmolality in the gel state, although it does contribute to the measured osmolality in the liquid state.

Topical drug delivery with polyoxyalkylene polymer thermoreversible gels

Isotonic, iso-osmotic, pH balanced thermoreversible gels are ideal vehicles for drug delivery to a body cavity of a mammal. The osmolality in the gel state can be calculated by assuming that a polyoxyalkylene block copolymer or polyether present in said gel does not contribute to the osmolality in the gel state, although it does contribute to the osmolality in the liquid state.

Body cavity drug delivery with thermoreversible gels containing

Balanced pH, thermo-irreversible polyoxyalkylene polymer and ionic polysaccharide gels are ideal materials for use as an ablatable mask or coating over the cornea of the eye of a mammal during excimer laser keratectomy. The depth and smoothness of the ablated corneal surface can be controlled by molding the desired surface curvature into the mask surface using a contact lens as a mold which is pressed onto the gel surface coating the cornea.

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Ann Arbor, MI, United States of America

Tacey X Viegas