Tsinghua University

Win Coat Corporation

National Science Council

Formosa Advanced Coating Technologies, Inc.

Wcc Biomedical Co., Ltd.

Ta-Jo Liu

Jane Wang

Yun-Wey Yu

Hsiu-Feng Yeh

Erh-Yeh Tsou

Yu-Sheng Lin

Yun-Hsuan Chen

Wen-Hsu Lien

Yi-Jyun Liao

Han-Yin Cheng

Wan-Hua Li

Hung-Hsing Lin

Shin-Yi Yin

Ying-Hua Hsu

E-Ron Chang

Yun-hsuan Chen

Provided is a method of preparing a biodegradable film, which comprises the steps of coating a soluble supporting solution on a substrate, coating a prepolymer solution, pre-drying, crosslinking, and separating. With the technical means, the method can separate the biodegradable film from the substrate smoothly, thereby ensuring the film integrity of the produced biodegradable film.

Method of preparing a biodegradable film

Provided is a microneedle patch comprising a substrate part and multiple needle parts protruding from the substrate part. The substrate part consists of a diffusion-proof layer and a base, and each needle part consists of a needle tip, a diffusion-proof layer and a base. The diffusion-proof layer of each needle part is formed between the needle tip and the base of the corresponding needle part. The diffusion-proof layer of the substrate part and the diffusion-proof layer of needle part are one-piece structures, and so are the base of the substrate part and the base of the needle part. The diffusion-proof layer of the microneedle patch can prevent the active ingredients from diffusing to the base, limit the active ingredients to the needle tip and control the carrying quantity thereof.

Multi-layered microneedle patch and method of manufacturing the same

The present invention relates to a base composition for a microneedle patch and a microneedle patch comprising the same. The base composition comprises a first HPMC, a second HPMC and PVP/VA, wherein the viscosity of the first HPMC is greater than that of the second HPMC, the weight ratio of the first HPMC relative to the second HPMC is 1:0.1 to 1:1.2, and the amount of the PVP/VA is 0.25 wt % to 2 wt %. By controlling the constitution of the base composition, the microneedle patch can not only be demolded smoothly during the stage of the production, but also obtain the desired softness, flatness, flexibility, skin adhesion during the stage of use and humidity resistance during the stage of storage.

Base composition for microneedle patch and microneedle patch comprising the same

The present invention discloses an apparatus for block type extrusion coating, and a process for forming block coating or grid-type coating on a substrate. The present invention uses a die set composed of an upper mold, a lower mold and a shim therebetween, which can be used to form a plurality of coated stripes. The present invention further uses several control valves, pumps and a controller to intermittently extrude a coating solution from the die set, so that the stripe coating is converted to a block coating. The block coated substrate can be rotated 90 degrees, followed by a stripe coating process to form a grid-type coating on the substrate.

Process and related apparatus for block coating

The invention is related to the formation of three different and repeated stripes abbreviate as ABCABC-typed or A_B_C-typed at the die exit. The symbol, &ldquo;_&rdquo;, implies that there is no coating between two adjacent stripes. In this invention a guide shim and a guide die are inserted between two coating dies. Three different coating solutions will flow into the die assembly through different inlet positions. Two of which are introduced from the two coating dies will flow through the multiple channels provided in the guide shim and the guide die respectively and then contact with each other and with the third solution introduced from a side of the guide die in the same slot section to form the ABCABC-typed stripes. The coating solutions can also flow through the multiple channels to the same slot section but not contact each other to form the A_B_C-typed stripes at the die exit with a modification of the die assembly.

Die set for preparing ABCABC multiple-stripe coating

This invention is related to a die set and method for the production of multiple stripes with two different materials A and B adjacent to each other. The special feature of this invention is that a specially designed shim is inserted between two pieces of coating dies. When liquids A and B enter the two sides of the die set separately, B liquid will flow through the distribution passages in the shim to form multiple stripes and then contact stripes of A liquid in the same slot section. The multiple stripes of repeated coating liquids that consists of ABAB patterns will be generated once the multiple stripes are coated and dried on the substrate.

Apparatus and method for forming a coating layer of multiple stripes

Growing community of inventors

Hsinchu, Taiwan

Ta-Jo Liu