Merck + Co., Inc.

Ta J Lee

William F Hoffman

Clarence S Rooney

Gerald E Stokker

Robert L Smith

George D Hartman

Wasyl Halczenko

Otto D Hensens

Edward S Inamine

Kenneth E Wilson

Henry Joshua

David R Houck

Michael S Schwartz

Wilbur J Holtz

Novel 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors are useful as antihypercholesterolemic agents and are represented by the following general structural formula (II): ##STR1##

HMG-CoA reductase inhibitors

HMG-CoA reductase inhibitors of formulae (I) and (II) are disclosed. ##STR1##

4-Substituted HMG-CoA reductase inhibitors

Mevinolin-like compounds in which the lactone is opened and the hydroxyl function produced thereby is replaced by an oxo function are potent HMG-CoA reductase inhibitors possessing one less asymmetric center.

Oxo-analogs of mevinolin-like antihyper-cholesterolemic agents

Novel 3-hydroxy-3-methylglutaryl-Coenzyme A(HMG-CoA) reductase inhibitors, which are useful as antihypercholesterolemic agents and are represented by the following general structural formulae (I) and (II) ##STR1## and pharmaceutically acceptable salts of the compound (II) in which Z is hydrogen are disclosed.

Antihypercholesterolemic compounds

Processes and intermediates are disclosed for the formation of compounds of formula (I) and (II): ##STR1##

3-keto HMG-CoA reductase inhibitors

Compounds of formula (I) and (II): ##STR1## are HMG-CoA reductase inhibitors.

Compounds of Formula (I) and (II): ##STR1## are HMG-CoA reductase inhibitors.

3-KETO HMG-CoA reductase inhibitors

4-substituted HMG-CoA reductase inhibitors

3-keto HMG-COA reductase inhibitors

Novel 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors are useful as anti-hypercholesterolemic agents and are represented by the following general structural formulae (I) and (II): ##STR1##

Novel HMG-CoA reductase inhibitors

Novel 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors which are useful as antihypercholesterolemic agents and are represented by the following general structural formulae (I) and (II): ##STR1## and pharmaceutically acceptable salts of the compounds (II) in which Z is hydrogen are disclosed.

Novel 3-hydroxy-3-methylglutary-coenzyme A (HMG-CoA) reductase inhibitors which are useful as antihypercholesterolemic agents and are represented by the following general structural formulae (I) and (II): ##STR1## and pharmaceutically acceptable salts of the compounds (II) in which Z is hydrogen are disclosed.

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Lansdale, PA, United States of America

Ta J Lee