Innopharmax, Inc.

Tsh Biopharm Corporation Ltd.

Ta-Chien Lu

Wei-Hua Hao

Tsung-Hsin Lin

A controlled release carvedilol formulation for less frequent, preferably once daily administration is described. The controlled release formulation comprises a therapeutically effective amount of carvedilol or a pharmaceutically acceptable salt thereof, a matrix forming polymer, a solubility enhancer and a pharmaceutically acceptable carrier. In one embodiment, a controlled release formulation having a therapeutically effective amount of carvedilol is contained in two or more subunits having different release profiles. The controlled release formulation is usable in the treatment and/or prophylaxis of one or more conditions such as cardiovascular disorders.

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Taipei, Taiwan

Ta-Chien Lu