Agilent Technologies, Inc.

Purdue Research Foundation

Ta-Chen Wei

Wu Chen

William E Barber

Xiaoli Wang

Hugh W Hillhouse

Yingyu Li

Charles Lofton

Vikrant N Urade

Michael P Tate

There is disclosed a method of producing etched non-porous particles. The method includes, in some examples, coating a non-porous particle with a hydrophilic polymer and treating the coated particle with acid or base. Also provided is etched non-porous particles capable of separating a variety of analytes, including biomolecules.

Etched non-porous particles and method of producing thereof

Modified silica particles are provided. Aspects of the particles include an outer layer that is composed of organically-modified silica comprising a siloxane-linked hydrophilic group, such as a charged functional group or a polar neutral functional group. The modified silica particles can form the basis of a variety of chromatography support materials. Also provided are methods of preparing the subject particles. Aspects of the methods include contacting silica particles with water, an ionic fluoride and an organosilane reagent comprising a hydrophilic moiety to produce modified silica particles wherein the hydrophilic moiety of the organosilane reagent is incorporated into an outer layer of the silica particles. Chromatography supports and kits including the subject particles and methods of using the same are also provided.

Functionalized particles having modified phases

The invention provides superficially porous metal oxide particles with precisely controlled particle density and to methods for their preparation and use, as well as to separation devices (e.g., high pressure liquid chromatography) having superficially porous particles.

Superficially porous particles with precisely controlled particle density, and methods of preparation and use thereof

Superficially porous particles are provided. Aspects of the superficially porous particles include a non-porous inner core and a porous outer shell that includes inner and outer porous regions. The inner porous region can include ordered cylindrical pores substantially perpendicular to the non-porous inner core. The outer porous region can include conical pores which extend to the surface of the particles and which are in fluid communication with the cylindrical pores of the inner porous region. Also provided are methods of making the subject superficially porous particles. Aspects of the methods include subjecting substantially solid inorganic oxide particles to agitation in an aqueous solution in the presence of a first cationic surfactant and a second anionic surfactant, which together form micelles, to pseudomorphically transform the particles.

Superficially porous particles with dual pore structure and methods for making the same

Superficially porous hybrid particles include hybrid solid cores that each contain an inorganic material and an organic material; and porous hybrid outer shells each include the inorganic and organic materials and having ordered pores, wherein the ordered pores have a median pore size ranges from about 15 to about 1000 &#x212b; with a pore size distribution (one standard deviation) of no more than 50% of the median pore size and produce at least one X-ray diffraction peak between 0.01&#xb0; and 10&#xb0; of a 2&#x3b8; scan range; wherein the particles have a median size range from about 0.5 &#x3bc;m to about 100 &#x3bc;m with a particle size distribution (one standard deviation) of no more than 15% of the median particle size, wherein the inorganic material comprises a metal oxide selected from silica, alumina, titania or zirconia.

Superficially porous metal oxide particles, methods for making them, and separation devices using them

Disclosed are porous-shell particles, methods of making the particles, and uses thereof. In one aspect, the porous-shell particles are superficially porous particles.

Superficially porous particles and methods of making and using same

The present invention is a process for making an inorganic/organic hybrid totally porous spherical silica particles by self assembly of surfactants that serve as organic templates via pseudomorphic transformation.

Inorganic/organic hybrid totally porous metal oxide particles, methods for making them and separation devices using them

Micelle-templated superficially porous particles having a solid core and an outer porous shell with ordered pore structures and a narrow particle size distribution, such as about &#xb1;5% (one sigma), and a high specific surface area of about 5 to about 1000 m/g.

A method for preparing functionalized porous particles is disclosed, the method comprising contacting a plurality of porous silica particles with water, at least one of an ionic fluoride such as HF or NHF or a basic activator, and a multifunctional organosilane. Also disclosed are functionalized porous silica particles produced from the methods disclosed herein.

Porous silica microspheres having organosilane modified surfaces

A method of forming a nanoporous film is disclosed. The method comprises forming a coating solution including clusters, surfactant molecules, a solvent, and one of an acid catalyst and a base catalyst. The clusters comprise inorganic groups. The method further comprises aging the coating solution for a time period to select a predetermined phase that will self-assemble and applying the coating solution on a substrate. The method further comprises evaporating the solvent from the coating solution and removing the surfactant molecules to yield the nanoporous film.

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Newark, DE, United States of America

Ta-Chen Wei