Vertex Pharmaceuticals, Inc.

St. Jude Children's Research Hospital

Coa Therapeutics, Inc.

T Jagadeeswar Reddy

John Patrick Maxwell

Simon Giroux

Laval Chan Chun Kong

Mark A Morris

James A Henderson

Sanjoy Kumar Das

Carl Poisson

Louis Vaillancourt

Oswy Z Pereira

Constantin G Yannopoulos

Guy Falardeau

Caroline Cadilhac

Jian Jim Wang

Albert Charles Pierce

Kevin Michael Cottrell

Robert J Zamboni

Govinda Rao Bhisetti

Richard Edward Lee

Ronald Lee Grey, Jr

Bingcan Liu

Monica Bubenik

Valerie Marone

Charles O Rock

Chitra Subramanian

Mi Kyung Yun

Suzanne Jackowski

Rajendra P Tangallapally

Anne V Edwards

Youssef L Bennani

Real Denis

Youssef Laafiret Bennani

Jiuyu Liu

Lalit Kumar Sharma

Youssef L Benanni

Bingan Liu

Richard E Lee

The present disclosure relates to chemical compounds that modulate pantothenate kinase (PanK) activity for the treatment of metabolic disorders (such as diabetes mellitus type II), neurologic disorders (such as pantothenate kinase-associated neurodegeneration), pharmaceutical compositions containing such compounds, and their use in treatment. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Small molecule modulators of pantothenate kinases

The present disclosure relates to methods of treating a coenzyme A reduction, elevation, sequestration, toxicity, or redistribution (CASTOR) disease such as, for example, defects in fatty acid oxidation enzymes, methylmalonic acidemia, glutaric acidemia, propionic academia, and HMG-CoA lyase, via small molecule modulators of CoA levels. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Methods of treating disorders associated with castor

Compounds represented by formula I or pharmaceutically acceptable salts thereof, wherein A, B, B', X, Y, R, R, R&#x2032;, R, R&#x2032;, R, R&#x2032;, R, R&#x2032;, m, n, or p are as defined herein, are useful for treating flaviviridae viral infections.

Analogues for the treatment or prevention of flavivirus infections

Compounds represented by formula I: or pharmaceutically acceptable salts and solvates thereof, wherein A, B, B', X, Y, R, R&#x2032;, R, R&#x2032;, R, R&#x2032;, R, R&#x2032;, R, m, n, or p are as defined herein, are useful for treating flaviviridae viral infections.

Benzimidazole analogues for the treatment or prevention of flavivirus infections

Growing community of inventors

Pierrefonds, Canada

T Jagadeeswar Reddy