Synaptic Pharmaceutical Corporation

T G Murali Dhar

Charles Gluchowski

Wai C Wong

Dhanapalan Nagarathnam

Mohammad R Marzabadi

George Chiu

Bharat Lagu

Yoon T Jeon

Shou Wu Miao

This invention is directed to novel imidazole and imidazoline derivatives which are selective agonists for cloned human &agr; adrenergic receptors. This invention is also related to the use of these compounds for the treatment of any disease where modulation of the &agr; receptors may be useful. The invention further provides for a pharmaceutical composition comprising a therapeutically effective amount of the above-defined compounds and a pharmaceutically acceptable carrier.

Imidazole and imidazoline derivatives and uses thereof

5-(heterocyclic alkyl)-6-aryl-dihydropyrimidines

This invention is directed to oxazolidinone compounds which are selective antagonists for human &agr; receptors. This invention is also related to uses of these compounds for lowering intraocular pressure, inhibiting cholesterol synthesis, relaxing lower urinary tract tissue, the treatment of benign prostatic hyperplasia, impotency, cardiac arrhythmia and for the treatment of any disease where the antagonism of the &agr; receptor may be useful. The invention further provides a pharmaceutical composition comprising a therapeutically effective amount of the above-defined compounds and a pharmaceutically acceptable carrier.

Oxazolidinones and uses thereof

This invention is directed to dihydropyrimidine compounds of the following formula:

This invention is directed to the use of dihydropyrimidine compounds, which are selective antagonists for cloned human &agr;,receptors, for the treatment of benign prostatic hyperplasia and other diseases where antagonism of the human &agr;,receptor is useful. The invention further provides a pharmaceutical composition comprising a therapeutically effective amount of the above-identified compounds and a pharmaceutically acceptable carrier.

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Newark, DE, United States of America

T G Murali Dhar