East Carolina University

Stryker European Operations Limited

Novadaq Technologies, Inc.

Novadaq Technologies Ulc

Stryker Corporation

T Bruce Ferguson, Jr

Cheng Chen

Peter Dvorsky

David Mark Henri Goyette

Kenneth Michael Jacobs

Bryent Tucker

Sunghan Kim

Zhiyong Peng

William Hempstead

A method to visualize, display, analyze and quantify angiography, perfusion, and the change in angiography and perfusion in real time, is provided. This method captures image data sequences from indocyanine green near infra-red fluorescence imaging used in a variety of surgical procedure applications, where angiography and perfusion are critical for intraoperative decisions.

Quantification and analysis of angiography and perfusion

Vessel perfusion and myocardial blush are determined by analyzing fluorescence signals obtained in a static region-of-interest (ROI) in a collection of fluorescence images of myocardial tissue. The blush value is determined from the total intensity of the intensity values of image elements located within the smallest contiguous range of image intensity values containing a predefined fraction of a total measured image intensity of all image elements within the ROI. Vessel (arterial) peak intensity is determined from image elements located within the ROI that have the smallest contiguous range of highest measured image intensity values and contain a predefined fraction of a total measured image intensity of all image elements within the ROI. Cardiac function can be established by comparing the time differential between the time of peak intensity in a blood vessel and that in a region of neighboring myocardial tissue both pre and post procedure.

Method for evaluating blush in myocardial tissue

Some embodiments of the present inventive concept provide a multispectral imaging system including a first light source, the first light source having a first wavelength configured to produce a non-coherent illumination to image a sample; a second coherent light source, different from the first light source, having a second wavelength, different from the first wavelength, configured to image the sample simultaneously with the first light source; a camera configured to simultaneously receive information related to the first and second light sources from the sample, wherein light at the first wavelength is configured to image a surface of the sample into the camera and light at the second wavelength is configured to penetrate the sample and provide information related to the penetrated sample to the camera; and a processor configured to combine the received information related to the first and second light sources and generate a synthesized image of the anatomical structure and the physiology of blood flow and perfusion of the sample in terms of blood flow rate distribution.

Determining peripheral oxygen saturation (SpO2) and hemoglobin concentration using multi-spectral laser imaging (MSLI) methods and systems

Multispectral imaging systems are provided including an illumination control module configured to image a sample and provide an imaging output sequence including images and data; a multi-spectral physiologic visualization (MSPV) module, a peripheral oxygen saturation (SpO) module and a physiologic status parameters (PSP) module configured to receive the imaging output sequence of the illumination control module simultaneously. The MSPV module is configured to provide real-time blood flow distribution visualization of a field of view (FOV) responsive to the received imaging output sequence. The SpOmodule is configured to provide real-time SpOinformation at a tissue surface level for the FOV responsive to the received imaging and output sequence. The PSP module is configured to derive status parameters in real-time from metadata associated with the received imaging and output sequence of the FOV. The system further includes a processing engine configured to integrate and analyze the real-time blood flow distribution visualization, SpOinformation and derived status parameters.

Systems for detecting vascular and arterial disease in asymptomatic patients and related methods

Multispectral imaging systems are provided including a first light source having a first wavelength configured to image a sample; a second light source, different from the first light source, having a second wavelength, different from the first wavelength, configured to image the sample; and at least a third light source, different from the first and second light sources, having a third wavelength, different from the first and second wavelengths, configured to image the sample. A camera is configured to receive information related to the first, second and at least third light sources from the sample. A processor is configured to combine the information related to the first, second and at least third light sources provided by the camera to image an anatomical structure of the sample, image physiology of blood flow and perfusion of the sample and/or synthesize the anatomical structure and the physiology of blood flow and perfusion of the sample in terms of a blood flow rate distribution. The imaging system is directed and focused on a field of view (FOV) in a region of interest of the sample using an endoscope.

Multi-spectral physiologic visualization (MSPV) using laser imaging methods and systems for blood flow and perfusion imaging and quantification in an endoscopic design

Some embodiments of the present inventive concept provide a system that uses two wavelengths of differential transmittance through a sample to apply laser speckle or laser Doppler imaging. A first of the two wavelengths is within the visible range that has zero or very shallow penetration. This wavelength captures the anatomical structure of tissue/organ surface and serves as a position marker of the sample but not the subsurface movement of blood flow and perfusion. A second wavelength is in the near Infra-Red (NIR) range, which has much deeper penetration. This wavelength reveals the underlying blood flow physiology and correlates both to the motion of the sample and also the movement of blood flow and perfusion. Thus, true motion of blood flow and perfusion can be derived from the NIR imaging measurement without being affected by the motion artifact of the target.

Growing community of inventors

Raleigh, NC, United States of America

T Bruce Ferguson, Jr