Becton Dickinson and Company Limited

Transgene S.a.

Geneohm Sciences, Inc.

Becton Dickinson Infusion Therapy Systems Inc.

Hemosystem

Sébastien Ribault

Jean-Pierre Hermet

Isabelle Besson-Faure

Yann Godfrin

Anne Monnot Des Angles

Majid Mehtali

Pascal Neuville

Isabelle Besson Faure

Thomas Vigneron

The invention concerns a device and a method for concentrating pathogenic germs potentially present in blood products or derivatives and for detecting said germs comprising the following steps: (a) subjecting a sample of said blood product to a blood cell aggregating treatment, (b) eliminating the aggregates formed at step (a) by passing the treated sample over a first filter allowing through the contaminating germs but not the cell aggregates, (c) selectively lyzing the residual cells of the filtrate obtained at step (b), (d) recuperating the contaminating germs by passing the lysate of step (c) over a second filter to detect the contaminating germs possibly trapped.

Device and method for concentrating and detecting pathogenic microbes from blood products and/or their derivatives

The invention concerns a device for preparing a body fluid for a bacteriological analysis thereof comprising a container provided with a chamber () wherein a piston () is mobile between an opening position and a closing position, the chamber () including a separation zone () and means for introducing () a fluid into said chamber and the piston () including a closure means () co-operating with the separation zone () so as to define an upper volume () and a lower volume () on either side of said zone, the upper volume () and the lower volume () mutually communicating when the piston () is in opening position and being tightly isolated from each other when the piston () is in closing position. The invention also concerns a preparation method using such a device ().

Device for preparing a body fluid for a bacteriological analysis

The invention concerns a device and a method for concentrating pathogenic germs potentiaily present in blood products or derivatives and for detecting said germs comprising the following steps: (a) subjecting a sample of said blood product to a blood cell aggregating treatment, (b) eliminating the aggregates formed at step (a) by passing the treated sample over a first filter allowing through the contaminating germs but not the cell aggregates, (c) selectively lyzing the residual cells of the filtrate obtained at step (b), (d) recuperating the contaminating germs by passing the lysate of step (c) over a second filter to detect the contaminating germs possibly trapped.

A method and device for continuously drawing and mixing liquid samples originating from at least two different containers are described. The device comprises a mixing chamber, which is connected to each of the containers. The device is characterized in that it comprises, between the container and the mixing chamber, at least one intermediate sample chamber for each container, being connected in order to transfer all or a portion of the sampled liquid to the mixing chamber. The device has a vertical configuration.

Method and device for drawing and mixing liquid samples

The present invention concerns a chimeric construct comprising a SMC-specific promoter operably linked to a muscle-specific enhancer. It also provides an expression cassette comprising such a chimeric construct to control expression of a therapeutic gene. Finally, the invention relates to a recombinant vector, a viral particle, an eukaryotic host cell, a composition comprising said expression cassette and their use for specific expression in SMCs and for therapeutic or prophylactic purposes, a method for the treatment of a human or animal organism as well as a transgenic non-human animal comprising integrated into its genome the chimeric construct, the expression cassette or the vector of the present invention.

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Plan de Cuques, France

Sébastien Ribault