Richter Gedeon Nyrt.

N-gene Research Laboratories, Inc.

Sándor Bernáth

Gábor Balogh

Ibolya Horváth

Ferenc Fülöp

Zsolt Török

László Vígh

Botond Penke

Ákos Hunya

Balázs Sümegi

Péter Literáti Nagy

Kálmán Tory

Zoltán Szilvássy

József Mandl

László Vigh

János Egri

Kálmán Takács

Attila Kolonics

The invention provides 1,4-dihydropyridine derivatives of formula (I) wherein Ris optionally substituted Caryl group or 5 to 6 membered heteroaryl group comprising 1 to 3 nitrogen atoms or other heteroatoms like oxygen and sulphur, and combinations thereof; Rand Rare independently hydrogen or Calkyl group; Rand Rare independently hydrogen, Calkyl group optionally substituted with amino, mono- or di(Calkyl)amino, or with 5 to 24 membered optionally fused heterocyclic ring attached by nitrogen and optionally comprising additional 1 to 3 N, O, S heteroatoms and optionally substituted with Calkyl group or Calkoxy group; Ris Calkyl, Ccycloalkyl, CcycloalkylCalkyl or arylCalkyl group; and stereoisomers including enantiomers, diastereomers, racemic mixtures, mixture of enantiomers and combination thereof, as well as polymorphs, pharmaceutically acceptable salts, solvates, esters and prodrugs thereof for use in the therapeutic or prophylactic treatment of a disorder mediated by heat shock proteins. 

1,4-dihydropyridine derivatives with HSP modulating activity

1,4-dihydropyridine derivatives with Hsp modulating activity

O-(3-piperidino-2-hydroxypropyl)-nicotinic amidoxime (BGP-15) or a pharmaceutically suitable acid addition salt thereof can be used for the prevention or reduction of weight gain or the reduction of the rate of body weight gain.

Prevention and treatment of obesity

Growing community of inventors

Telki, Hungary

Sándor Bernáth