Oxford Nanopore Technologies Limited

Szabolcs Soeroes

Andrew John Heron

Elizabeth Jayne Wallace

Mark Bruce

Ruth Moysey

Lakmal Nishantha Jayasinghe

Rebecca Victoria Bowen

Luke McNeill

Domenico Caprotti

James White

John Milton

David Alves

James Anthony Clarke

Joseph Hargreaves Lloyd

Christopher Peter Youd

Clive Gavin Brown

Mihaela Misca

Antonino Puglisi

Anthony Clarke

Luke Mcneill

David Antoni Alves

The invention relates to a new method of characterising a target polynucleotide. The method uses a pore and a Dda helicase. The helicase controls the movement of the target polynucleotide through the pore. The invention also relates to modified Dda helicases which can be used to control the movement of polynucleotides and are particularly useful for sequencing polynucleotides.

Modified helicases

The invention relates to modified helicases with reduced unbinding from polynucleotides. The helicases can be used to control the movement of polynucleotides and are particularly useful for sequencing polynucleotides.

The invention relates to modified Dda helicases which can be used to control the movement of polynucleotides and are particularly useful for sequencing polynucleotides.

Modified enzymes

The invention relates to new methods of controlling the movement of polynucleotides through transmembrane pores. The invention also relates to new methods of characterizing target polynucleotides using helicases.

Method for controlling the movement of a polynucleotide through a transmembrane pore

The invention relates to a new method of characterizing a target polynucleotide. The method uses a pore and a RecD helicase. The helicase controls the movement of the target polynucleotide through the pore.

Enzyme method

The invention relates to methods using constructs comprising a helicase and an additional polynucleotide binding moiety. The helicase is attached to the polynucleotide binding moiety and the construct has the ability to control the movement of a polynucleotide. The constructs can be used to control the movement of polynucleotides and are particularly useful for sequencing polynucleotides.

Enzyme construct

The invention relates to a new method of characterizing a target polynucleotide. The method uses a pore and an XPD helicase. The helicase controls the movement of the target polynucleotide through the pore.

Method for characterising a polynucleotide by using a XPD helicase

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Oxford, United Kingdom

Szabolcs Soeroes