Plus Chemicals, B.v.

Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag

Teva Gyógyszergyár Zárkörüen Müködö Részvénytársaság

Szabolcs Salyi

Csaba Szabo

Ferenc Korodi

Erzsebet Meszaros Sos

Claude Singer

Viktor Gyollai

Tivadar Tamas

Sandor Janos Molnar

David Leonov

Istvan Bodi

Melczer Istvan

Szabo Csaba

The invention relates to a process for the synthesis of Aztreonam. Specifically, the process entails hydrolyzing [3S-[3&#x3b1;(Z),4&#x3b2;]]-3-[[(2-amino-4-thiazolyl)[(1-t-butoxycarbonyl-1-methylethoxy)imino]acetyl]amino]-4-methyl-2-oxo-1-azetidinesulfonic acid (t-Bu Aztreonam) to form Aztreonam.

Preparation of Aztreonam

A process for preparing ondansetron by transamination of an ondansetron structural analog that can be readily prepared conveniently by a Mannich reaction is provided. The process represents an improvement upon known procedures for making ondansetron by transamination because of its rapid rate, selectivity and the ease with which the product can be isolated from the reaction mixture.

Process for preparing 1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-YL)methyl]-4H-carbazol-4-one

The present invention relates to a process for preparing simvastatin, wherein the simvastatin dimer content is controlled. More particularly, the present invention relates to a process for preparing simvastatin having a simvastatin dimer content of about 0.2 to about 0.4% wt. The present invention also relates to a process for preparing simvastatin having a simvastatin dimer content of less than about 0.2% wt. The present invention also discloses a commercial scale process of preparing simvastatin having a specified simvastatin dimer content which is reproducible.

Process for preparing simvastatin having controlled ranges of simvastatin dimer content

The present invention relates to a process to prepare semi synthetic statins, to intermediates formed during said process and to highly purified simvastatin produced by the process.

Highly purified simvastatin compositions

Growing community of inventors

Debrecen, Hungary

Szabolcs Salyi