Sankyo Company, Limited

Syunji Naruto

Kazuo Koyama

Atsusuke Terada

Shinji Marumoto

Tetsuo Miyadera

Toshiharu Kamioka

Sebastian Lazareno

Nigel Birdsall

Ryuji Tachikawa

A compound of formula (I): ##STR1## wherein Y.sup.1, Y.sup.2, Y.sup.3 and Y.sup.4 are each hydrogen, halogen, nitro, cyano, hydroxyl, thiol, amino, alkyl, haloalkyl, alkylthio, a protected or unprotected carboxyl, a protected or unprotected sulfonamide, or tetrazol; one of R.sup.1 and R.sup.2 is hydrogen, alkyl, aryl, aralkyl, oxazolyl, or a protected or unprotected carboxyl and the other of R.sup.1 and R.sup.2 is hydrogen, alkyl, aryl or aralkyl; and R.sup.3 is hydrogen or an amino protecting group, and pharmaceutically acceptable salts or esters thereof. The compounds are effective for treating dementia, Alzheimer's disease and delirium and are effective as sedatives.

Heterocyclic compounds, their preparation and their therapeutic use

Aminoalkanol derivatives having the formula ##STR1## wherein R.sub.1 represents hydrogen atoms or a halogen atom, R.sub.2 represents hydrogen atom or fluorine atom and A represents an alkylene group having 1-4 carbon atoms. The aminoalkanol derivatives are useful as a minor tranquilizer and can be prepared by reacting the corresponding 2-amino-.alpha.-phenylbenzylideneaminoalkanol derivative with an aminocarboxylic acid.

2-Aminoacetamido-.alpha.-phenylbenzylideneaminoalkanol derivatives and

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Yokohama, Japan

Syunji Naruto