Teijin Limited

The Chemo-Sero-Therapeutic Research Institute

Syoji Ono

Tsunemasa Yoshida

Yuji Fukumoto

Takashi Sugiyama

Yataro Ichikawa

Yoji Suzuki

Shuzi Miura

Hitoshi Ohmori

Akiko Azuma

Yoshiko Kawakami

An immunoglobulin composition comprising an immunoglobulin, and as an aggregation preventing agent or an aggregate dissociating agent for the immunoglobulin, about 1 to about 600% by weight, based on the weight of the immunoglobulin, of a water-soluble acid additive salt of a basic nitrogen-containing organic compound containing one or more basic nitrogen atoms in the molecule and optionally carboxyl groups in smaller number than the basic nitrogen atoms and having a pKb at 25.degree. C. of not more than 7; and a method for producing an immunoglobulin composition having a high monomer content, which comprises contacting an immunoglobulin in aqueous solution with about 1 to about 600% by weight, based on the weight of the immunoglobulin, of a water-soluble acid addition salt thereby to prevent aggregation of the monomer of the immunoglobulin, and when the immunoglobulin contains aggregated molecules, dissociating the aggregated molecules into monomers, and thereafter, if desired, lyophilizing the resulting product.

Immunoglobulin composition having a high monomer content, and process

The present invention is directed to an S-sulfonated immunoglobulin composition comprising an S-sulfonated immunoglobulin and as an aggregation preventing agent or an aggregate dissociating agent, therefor, about 1 to about 600% by weight, based on the weight of the S-sulfonated immunoglobulin, of a water-soluble acid addition salt of a basic nitrogen-containing organic compound containing one or more basic nitrogen atoms in the molecule and optionally carboxyl groups smaller in number than the basic nitrogen atoms and having a pKb at 25.degree. C. of not more than 7. There is also provided a process for producing an S-sulfonated immunoglobulin composition having a high monomer content, which comprises contacting an S-sulfonated immunoglobulin in aqueous solution with about 1 to about 600% by weight, based on the weight of the S-sulfonated immunoglobulin, of the water-soluble acid addition salt, or reacting an immunoglobulin in aqueous solution with a compound capable of yielding a sulfite ion in water and an oxidizing agent in the presence of about 1 to about 600% by weight, based on the immunoglobulin, of the water-soluble acid addition salt.

S-Sulfonated immunoglobulin composition having a high monomer content

Process for the preparation of immunogammaglobulin using trithionate

This invention provides novel penicillin derivatives of formula [I]; ##STR1## wherein A is hydrogen or hydroxyl, and B represents the cumarin nucleus of formula [III-a]; ##STR2## in which B.sub.1, B.sub.2, B.sub.3, B.sub.4 and B.sub.5 are same or different, and are hydrogen or substituent groups that may contain nitrogen, sulfur or oxygen atom, or nontoxic salts thereof, and bactericides containing said novel penicillin derivatives or nontoxic salts thereof as the main ingredient, and also an advantageous process for producing said novel penicillin derivatives or nontoxic salts thereof, which comprises reacting a derivative of .alpha.-aminobenzylpenicillin with a coumarincarboxylic acid or reacting 6-aminopencillanic acid, a carboxylic acid salt thereof or a protected derivative thereof having the carboxyl blocked with a readily removable protecting group, with a coumarincarboxylic acid phenylglycinamide.

Novel penicillin derivatives containing a coumarin nucleus and medicines

Growing community of inventors

Kodaira, Japan

Syoji Ono