Uniwersytet Warszawski

Sylwia Walczak

Jacek Jemielity

Joanna Kowalska

The object of the invention is a compound of formula (I), or a stereoisomer or salt thereof, wherein Rand Rare selected from the group consisting of N, N+&#x2014;CH, N&#x2014;CH, N&#x2014;CH, N&#x2014;CH, N&#x2014;CHCHwherein at least one of R, Ris not N. n and m are independently chosen from the group consisting of 0, 1 and 2; X is selected from the group consisting of O, NH, S, CHk is 1 or 2 Y is either void or selected from the group of &#x2014;CH&#x2014;, &#x2014;CHCH&#x2014;, &#x2014;CHO&#x2014;, &#x2014;CHS&#x2014;, &#x2014;CHNH&#x2014;, &#x2014;CHCHO&#x2014;, &#x2014;CHCHNH&#x2014;, &#x2014;CHCHS&#x2014; R, R, R, Rare selected from the group consisting of H, OH, OCH, or OCHCH; wherein Rand Rmay be the same or different; Rand Rmay be the same or different; if either of R, Ris different than OH than Rand Rare both OH; if either of R, Ris different than OH than Rand Rare both OH. The object of the invention is also a composition comprising the compound of the invention, an RNA molecule incorporating the same, uses thereof and a method of synthesizing, in vitro or in vivo, the RNA molecule, as well as a method of synthesizing a protein or peptide in vitro, or in vivo or in cultured cells, said method comprising translating the RNA molecule. 

Phosphotriazole MRNA 5'-end cap analogs, composition comprising the same, RNA molecule incorporating the same, uses thereof and method of synthesizing RNA molecule, protein or peptide

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Opacz Kolonia, Poland

Sylwia Walczak