Institut Pasteur

Sylvie Van Der Werf

Marc Girard

Pierre Lafaye

Etienne Simon-Loriere

Nicolas Escriou

Jacques Bellalou

Caroline Demeret

Stéphane Petres

Mélanie Albert

Sylvie Behillil

Pascal Pineau

Vincent Enouf

Flora Donati

Agnés Marchio

Frédéric Lemoine

Christophe Malabat

The invention relates to the diagnosis of a SARS-associated coronavirus, such as a SARS-CoV-2 infection and SARS-CoV-1 infection, using the N_SARS-CoV-1 and N_SARS-CoV-2 proteins and antibodies binding to these proteins. The invention reagents, methods and kits for the detection of a SARS-associated coronavirus.

Severe acute respiratory syndrome (SARS)—associated coronavirus diagnostics

The invention relates to the diagnosis of a SARS-associated coronavirus, such as a SARS CoV-2 infection and SARS-CoV infection, using the SARS-CoV and SARS-CoV-2 nucleocapsid proteins and antibodies binding to these proteins. The invention encompasses reagents, methods and kits for the detection of a SARS-associated coronavirus.

Severe acute respiratory syndrome (SARS)-associated coronavirus diagnostics

Methods, primers, sets of primers, probes, compositions, and kits for detecting presence or absence of SARS-CoV-2 in a sample are provided.

Methods and reagents for the specific and sensitive detection of SARS-CoV-2

Severe acute respiratory syndrome (SARS)&#x2014;associated coronavirus diagnostics

The invention relates to a DNA fragment containing at the most 315 pairs of nucleotides coding for a peptide which can be recognized by antibodies acting both against the 'C' and 'D' particles of the same poliovirus and against the VP-1 structural polypeptide of the capsid of this poliovirus. This peptide contains in particular the following sequence:

Peptides comprising an immunogenic site of poliovirus and DNAs

The invention relates to a DNA fragment containing at the most 315 pairs of nucleotides coding for a peptide which can be recognized by antibodies acting both against the 'C' and 'D' particles of the same poliovirus and against the VP-1 structural polypeptide of the capsid of this poliovirus. This peptide contains in particular the following sequence: Asp Asn Pro Ala Ser Thr Asn Lys Asp Lys Leu.

DNA fragment capable of coding for an immunogenic peptide capable of inducing in vivo antibody reacting with anti-poliovirus. It possesses up to the order of 1.2 kilobase pairs and contains a nucleotide sequence coding for the poliovirus VP1 protein.

DNA fragments coding an immunogen peptide liable of inducing in vivo

Peptides which can be recognized by antibodies acting both against the 'C' and 'D' particles of the same poliovirus and against the VP-1 structural polypeptides of this capsid of the poliovirus. These peptides comprise the amino acid sequence: Asp Asn Pro Ala Ser Thr Thr Asn Lys Asp Lys Leu; and one or more additional amino acids in a specified sequence.

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Paris, France

Sylvie Van Der Werf