Universitéde Montreal

Valorisation-recherche, Societe En Commandite

Valorisation Hsj, Societe En Commandite

Sylvie Marleau

Huy Ong

André Tremblay

Ramesh Chingle

Dilan Mukandila Mulumba

Ahsanullah

Jinqiang Zhang

Ragnhild Gaard Ohm

William D Lubell

Samy Omri

Novel cyclic peptide GHRP-6 analogs of formula (I): (I) or pharmaceutically acceptable esters or salts thereof, are described. These cyclic peptide GHRP-6 analogs may be used for modulating CD36 activity, for example for the treatment of CD36-related diseases, disorders or conditions in a subject, such as atherosclerosis and age-related macular degeneration.

Cyclic peptides and uses thereof

According to the invention there is provided a method of treatment or prophylaxis of atherosclerosis, hypercholesterolemia or a cardiovascular disease associated with atherosclerosis, which method comprises administration of one or more Growth Hormone Releasing Peptides (GHRPs) to a patient in need of such treatment or prophylaxis. There are also provided methods of reducing blood plasma cholesterol levels, as well as methods of modulating the expression of the scavenger receptor CD36 and genes involved in cellular cholesterol efflux.

Growth hormone-releasing peptides in the treatment or prevention of atherosclerosis and hypercholesterolemia

Growing community of inventors

Rosemère, Canada

Sylvie Marleau