Centre National De La Recherche Scientifique

Université Nice Sophia Antipolis

Centre National De La Recherche Scientifique-Cnrs

Sylvie Diochot

Michel Lazdunski

Éric Lingueglia

Pierre Escoubas

Anne Baron-Forster

Miguel Salinas

Emmanuel Deval

Jacques Noel

Jan DeWeille

Novel isolated peptides which induce analgesia and which inhibit ASIC channels (Acid Sensing Ion Channels), to the polynucleotides encoding these peptides, and also to the pharmaceutical compositions, host cells, and vectors comprising these peptides and the polynucleotides encoding these peptides. In particular, these peptides are isolated from the venom of the snake. The present invention also relates to the use of these peptides as a diagnostic tool or as a medicament, particularly as an analgesic, or for identifying analgesic molecules or molecules which inhibit ASIC channels.

Peptides which have analgesic effects and which inhibit ASIC channels

The invention relates to the use of the peptide toxin APETx2 that blocks the ASIC3 cationic channels and that is derived from thesea anemone, and to the use of the analogs and derivatives thereof as a drug, particularly as an analgesic pain associated with the activation of ASIC3 (Acid Sensing Ion Channel 3) channels, in particular pain occurring upon an inflammation and potentially upon any painful situation associated with tissue acidosis (ischemiae, fractures, hematoma, oedema, phlyctena, local infections, tissue lesions, ocular wounds, tumours, etc.).

Method of treating pain or itching with APETx2 peptide toxin

The invention relates to a substantially pure polypeptide functioning as an ASIC1a channel blocker. Also provided is a nucleic acid molecule coding such polypeptide, pharmaceutical composition containing such polypeptide and a method of manufacturing an ASIC1a channel blocker.

Polypeptide inhibiting a proton-gated Na+ channel, a nucleic acid coding for such polypeptide and a method of manufacturing an ASIC1a channel blocker

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Valbonne, France

Sylvie Diochot