Institut National De La Sante Et De La Recherche Medicale

National University of Singapore

Institut Pasteur De Lille

Sylvie Claudette Alonso

Camille Locht

Rui Li

Rui Fen Annabelle Lim

Vincent Chow

Annabelle Rui Fen Lim

A CyaA-deficientmutant was constructed and used in a vaccine. The pertussis-specific antibody profile and Th17 response induced by vaccination with the mutant was surprisingly comparable to that induced bystrains not deficient in CyaA.

Prevention of pertussis using adenylate cyclase deficient Bordetella strains

A CyaA-deficientmutant was constructed and used in a vaccine. The-specific antibody profile and Th17 response induced by vaccination with the mutant was surprisingly comparable to that induced bystrains not deficient in CyaA.

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Adenylate cyclase deficient bordetella strains

The invention relates to compositions and vaccines that include a mutatedstrain for treating or preventing an influenza infection in a mammal. In addition, the invention further provides methods for protecting a mammal against infection by influenza and/or eliciting an immune response against an influenza virus in a mammal using the composition or vaccine.

Influenza vaccine, composition, and methods of use

Described herein are compositions, vaccines, and methods that include use of a mutatedstrain against allergic diseases such as asthma and skin inflammation. Also described are kits. Other compositions, vaccines, and methods are also described.

Growing community of inventors

Singapore, Singapore

Sylvie Claudette Alonso