US Government as Represented by the Secretary of the Army

The United States of America as Represented by the Department of Health

Sylvia N Calderon

Kenner C Rice

Frank Casper Tortella

Mark A DeCoster

Compositions having neuroprotective and analgesic activity

Compounds of the formula: ##STR1## wherein R.sup.1 and R.sup.2 are alkyl of 1-8 carbons have been shown to have both neuroprotective and analgesic activities. The compounds of the invention may be used in treatment of conditions that would normally result in neuronal damage, including those arising on account of cerebral ischemia/hypoxia or increase in intracranial pressure such as neoplasms, stroke, meningitis or trauma. Compositions of the invention can also be useful for treatment of toxin-related damage such as drug over-dose or exposure to toxins in the environment.

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Potomac, MD, United States of America

Sylvia N Calderon