Cellectis S.a.

Cellectis

Sylvestre Grizot

Mark Isalan

Luis Serrano Pubul

François Stricher

Emmanuel Fajardo Sanchez

A new I-CreI derived single-chain meganuclease comprising two domains, each domain comprising a portion of a parent I-CreI monomer which extends at least from the beginning of the first alpha helix to the end of the C-terminal loop and said two domains being joined by a peptidic linker which allows them to fold as a I-CreI dimer that is able to bind and cleave a chimeric DNA target comprising one different half of each parent homodimeric I-CreI meganuclease target sequence. Use of said I-CreI derived single-chain meganuclease for genetic engineering, genome therapy and antiviral therapy.

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La Garenne Colombes, France

Sylvestre Grizot