The Ohio State University

Astra Aktiebolag

Sylvan G Frank

Arne F Brodin

Chih-Ming J Chen

Arne Brodin

Levon Bostanian

Lisbet Rydhag

Fredrik Broberg

Siriporn Panthuvanich

Ratnesh Shrivastava

Shulin Ding

The present invention relates to an injectable solution for administration of one or more active compounds. According to the invention the active compound, which is in its neutral form, is dissolved in a biologically acceptable solvent whereby the active compound by administration precipitates, forming a solid phase of the solution in situ. Thus, said solution, which is easy to sterilize, is acting like a suspension when injected.

Precipitation of one or more active compounds in situ

Small particle formation

The present invention is concerned with the simultaneous formation and encapsulation of small particles from aqueous solutions of compounds whose solubility is greater at a first pH than at a second pH. The process is preferably used to prepare a readily soluble encapsulated pharmaceutically active compound.

Small particule formation and encapsulation

The present invention is concerned with the simultaneous formation and encapsulation of small particles of organic compounds whose solubility in water is greater at a first pH than at a second pH by concurrently precipitating said organic compounds as small particles and forming a coacervate of an anionic (or cationic) surfactant and an amphoteric surfactant. The process is preferably used to prepare a readily soluble encapsulated pharmaceutically active compound.

Process for the formation and the simultaneous encapsulation of small particles of a compound from solution which comprises:

Small particle formation and encapsulation

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Columbus, OH, United States of America

Sylvan G Frank