Sanofi-A Ventis Deutschland Gmbh

Aventis Pharma S.a.

National Institute of Health and Medical Research

Sanofi-Aventis

Institut National Sante Et Recherche Medicale

Sylvain Ricard

Sandrine Mace

Detlef Kozian

Jean-Francois Deleuze

Karl-Ernst Siegler

Patrice Denefle

Evi Kostenis

Alexis Brice

Stefan Schaefer

Bernward Schoelkens

Sandrine Bouley

Nacer Eddine Abbas

Christophe Lucking

Martina Jacobs

Matthias Herrmann

Laurent Pradier

Joerg Czech

Jésus Benavides

Emmanuelle Cousin

Jean-François Deleuze

Jesus Benavides

The invention concerns nucleic acids coding for mutated or truncated forms of the human parkin gene, or forms comprising multiplication of exons, and the corresponding proteins and antibodies. The invention also concerns methods and kits for identifying mutations of the parkin gene, and for studying compounds for therapeutic purposes.

Mutations of the parkin gene, compositions, methods and uses

Mutations of the parkin gene

The present invention is directed to a method identifying a risk for a thrombogenic disorder including, without limitation, atrial fibrillation, stroke, prolonged intermitted neurological deficit (PRIND), transitory ischemic attack (TIA), atherosclerotic cerebrovascular disease (CVD) and/or coronary heart disease, as well as to a method for selecting patients with a risk for a thrombogenic disorder, to a method for identifying a pharmaceutical for the therapy or prophylaxis of a thrombogenic disorder as well as to a method for producing a medicament and a diagnostic by employing the TAFI-Ile347 polymorphism.

Method for the identification of a risk for a thrombogenic disorder by determining the TAFI-Ile347 polymorphism

The present invention relates to a method of identifying an increase in risk for type II Diabetes mellitus, venous thrombosis, or pulmonary embolism in a subject, wherein the presence of an amino acid exchange at position 286 from valine (Val) to alanine (Ala) in the EDG5 protein in a biological sample taken from the subject.

Association of EDG5 polymorphism V286A with type II diabetes mellitus and venous thrombosis/pulmonary embolism and the use thereof

The use of the single nucleotide polymorphism (SNP) at position &#x2212;(97) of the GIP gene for the identification of a cardiovascular disease or of an increased risk for developing a cardiovascular disease in a biological sample taken from an individual to be examined.

Use of a GIP promoter polymorphism

The present invention is directed to a method identifying a risk for a thrombogenic disorder, to a method for selecting patients with a risk for a thrombogenic disorder, to a method for identifying a pharmaceutical for the therapy or prophylaxis of a thrombogenic disorder as well as to a method for producing a medicament and a diagnostic by employing the TAFI-Ile347 polymorphism.

Method for the identification of a risk for a thrombogenic disorder by determining the TAFI-lle347 polymorphism

The invention relates to polynucleotide sequences comprising genetic variations of the PAR1 gene at positions 3090 and/or 3329. The occurrence of these variants in humans correlates with increased occurrence of particular cardiovascular disorders. The invention furthermore relates to methods for detecting said genetic variations for the purpose of patient diagnosis.

Analysis and use of PAR1 polymorphisms for evaluating the risk of cardiovascular disorders

The present invention relates to a method for diagnosing an individual for early onset Alzheimer's disease by measuring the presence or absence of the minor allele of the rs908832 polymorphism of the ABCA2 gene. The presence of the minor allele of the rs908832 polymorphism of the ABCA2 gene indicates that the individual may be suffering from Alzheimer's disease or exhibits an increased risk of developing Alzheimer's disease.

Method for detecting Alzheimer's disease

The present invention refers to a method of diagnosis of a predisposition to develop thrombotic disease, to test systems and their use for the diagnosis of a predisposition to develop thrombotic disease, to a PXpromoter variant and its use for screening for an anti-thrombotic agent, and to methods for identifying an individual that can be prophylactically or therapeutically treated with an anti-thrombotic agent, or for adapting a therapeutic or prophylactic dose of an anti-thrombotic agent.

Method of diagnosis of a predisposition to develop thrombotic disease and its uses

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Paris, France

Sylvain Ricard