Johnson & Johnson Consumer Companies, Inc.

Edison Pharmaceuticals, Inc.

Sylvain Gilat

Guy M Miller

Wei Zhang

Jian Chen

Bing Wang

Yong-Kang Zhang

Jiangao Song

Sekhar S Boddupalli

Lesley A Brown

Ughetta Del Balzo

Gary Binyamin

Steven Bobzin

Cytoprotective compounds, many of which are phenolic derivatives characterized by a substituted phenol having certain conjugated bonds, are useful in the treatment of certain ischemic or inflammatory conditions, including but not limited to stroke, myocardial infarction, congestive heart failure, and skin disorders characterized by inflammation or oxidative damage. They are also useful in the manufacture of pharmaceutical and cosmetic formulations for the treatment of such conditions.

Cytoprotective compounds, pharmaceutical and cosmetic formulations, and methods

The present invention is directed to rapid and efficient methods of identifying therapeutic compounds by allowing only the most favorable molecules initially selected based on their physical-chemical profile falling within a range predefined by the physical-chemical/biological relationship of a previously tested small subset of compounds of same core structure to be assayed; and to the therapeutic compositions identified by said methods.

Identifying therapeutic compounds based on their physical-chemical properties

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San Francisco, CA, United States of America

Sylvain Gilat