Georgetown University

National Institutes of Health, a Component of the US Dept. of Health & Human Services

Syed R Husain

Aquilur Rahman

Rafael Rafaeloff

Raj K Puri

Kathryn C Zoon

Daniel S Green

Methods and compositions are disclosed for treating a subject with a cancer. The compositions can include a chimeric molecule comprising an agent that specifically binds the interleukin 4 receptor (IL-4R) and a toxic moiety, an interferon alpha (IFN&#x3b1;), and an interferon gamma (IFN&#x3b3;). In some non-liming embodiments, the compositions can also include monocytes. The methods disclosed herein include administering a therapeutically effective amount of the compositions taught herein to a subject with cancer, thereby treating the cancer in the subject, wherein cells in the cancer express IL-4R. In some non-liming embodiments, the methods can also include administering monocytes.

Synergistic combination of IL-4, interferon gamma, and interferon alpha in treating ovarian cancer

Liposomal-encapsulated taxol or an antineoplastic derivative thereof or a mixture thereof is provided which is used to effect a therapeutically enhanced method of treating cancer, and which may be used advantageously in combination with hyperthermia. The liposomes confer enhanced stability and solubility to taxol or derivatives thereof.

Liposome encapsulated toxol and a method of using the same

Liposome encapsulated taxol and a method of using the same

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Gaithersburg, MD, United States of America

Syed R Husain