Abbott Cardiovascular Systems, Inc.

Advanced Cardiovascular Systems, Inc.

Syed Faiyaz Ahmed Hossainy

Stephen D Pacetti

Lothar W Kleiner

Mikael Trollsas

Michael H Ngo

Thierry Glauser

Yiwen Tang

David C Gale

Yunbing Wang

Ni Ding

Bin Huang

Eugene T Michal

Paul M Consigny

Charles David Claude

Florian Ludwig

Vincent J Gueriguian

Connie S Kwok

Kimchi Tran

John Joseph Stankus

John E Papp

Florencia Lim

Fuh-Wei Tang

Irina Astafieva

Gordon S Stewart

Garth L Wilkes

Jessica Reneé DesNoyer

Hugh Zhao

Paul John Kawula

Chad Joseph Abunassar

Evgenia Mandrusov

Benjamyn Serna

Jessica R DesNoyer

Boris Anukhin

Deborah L Kilpatrick

Jeffrey T Ellis

Lewis B Schwartz

O Mikael Trollsas

Gina Zhang

Qing Lin

Shaw Ling Hsu

William Earl Webler, Jr

Dariush Davalian

Murthy V Simhambhatla

Bozena Zofia Maslanka

Benny Serna

Gene Park

Dary Mirzaee

John S Stankus

Homayon Askaryar

Wouter Erik Roorda

Yatheendhar D Manicka

Timothy A Limon

Shubhayu Basu

Kevin Joe Ehrenreich

Klaus Kleine

Srinivasan Sridharan

Steven Z Wu

John L Toner

Christopher Feezor

Jessica G Chiu

Stephen R Dugan

Judy A Guruwaiya

Deborra Sanders Millare

Joel Harrington

Sameer Harish

Matthew M Mack

Nam D Pham

David J Sherman

Jessica Renee DesNoyer

Nancy Kirsten

Jeffrey Allen Spaeder

Maricela Kezis

Jessica Reneé´ DesNoyer

Harshad Borgaonkor

Anne Moberg Abreu

Bioabsorbable scaffolds having high crush recoverability, high fracture resistance, and reduced or no recoil due to self expanding properties at physiological conditions are disclosed. The scaffolds are made from a random copolymer of PLLA and a rubbery polymer such as polycaprolactone.

Shape memory bioresorbable polymer peripheral scaffolds

A braided polymeric scaffold, made at least in part from a bioresorbable material is deployed on a catheter that uses a push-pull mechanism to deploy the scaffold. A drug coating is disposed on the scaffold. A plurality of scaffold segments on a catheter is also disclosed.

Braided scaffolds

The present invention provides a semi-crystalline polymer for a coating on an implantable device for controlling release of drug and methods of making and using the same.

Bioabsorbable semi-crystalline polymer for controlling release of drug from a coating

A method including percutaneously positioning a delivery device in a blood vessel; locally introducing a treatment agent from the delivery device into the blood vessel upstream of an infarcted area or distressed area; and following introducing the treatment agent, occluding the blood vessel for a dwell time sufficient to allow the treatment agent to flow into targeted capillaries in or adjacent to the infarcted area. A system comprising a delivery device suitable for percutaneous insertion into a blood vessel of a patient, the delivery device comprising an occluding portion and a delivery cannula having a lumen therethrough; a controller coupled to a proximal portion of the delivery device comprising instruction logic to perform a method including introducing a treatment agent into the delivery cannula; and occluding a blood vessel following a predetermined delay time after introducing the treatment agent.

System for the injection of cells and/or biologically active materials into coronary arteries for therapeutic purposes

Segmented scaffolds composed of disconnected scaffold segments with overlapping end rings are disclosed. Scaffolds with at least one discontinuous link are also disclosed.

Segmented scaffold designs

A biocompatible plasticizer useful for forming a coating composition with a biocompatible polymer is provided. The coating composition may also include a biobeneficial polymer and/or a bioactive agent. The coating composition can form a coating on an implantable device. The implantable device can be used to treat or prevent a disorder such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof.

Plasticizers for coating compositions

A catheter configured for performing reperfusion by alternatively occluding a vessel so as to prevent fluid flow and removing that occlusion to allow fluid flow is described. A first catheter includes an outer member and a retractable valve to allow and prevent fluid flow in the vessel. A second catheter includes a sheathed expansion member that can be deployed and recaptured to prevent and allow, respectively, fluid flow. A third catheter includes an angioplasty balloon to open a vessel occlusion, in which an occlusion balloon is used to allow and disallow fluid flow. A fourth catheter includes an expandable member for providing mechanical plunging action to urge thrombotic material to a more distal location. A fifth catheter includes an accessory catheter that can be used to perform reperfusion with another catheter. A sixth catheter includes an inner balloon within an outer balloon configured to perform reperfusion.

Reperfusion injury devices

A polymer comprising phospholipid moieties and a biocompatible polymer backbone, a composition comprising the polymer and optionally a bioactive agent, an implantable devices such as a drug eluting stent comprising thereon a coating comprising the polymer and optionally a bioactive agent, and a method of using the device for the treatment of a disorder in a human being are provided.

Phosphoryl choline coating compositions

A composition that includes a bioactive agent-containing polymeric nanoparticle and a polymeric non-spherical microparticle, and methods of using such a composition to treat a vascular disease are disclosed.

Therapeutic composition with enhanced vessel targeting

A prodrug comprising a heparin and a drug is provided. The prodrug can be used to form a coating on a medical device. The prodrug can also be used with a polymeric material to form a coating on a medical device. The polymeric material can be a hydrophobic polymer, a hydrophilic polymer, a non-fouling polymer, or combinations thereof. The medical device can be implanted in a human being for the treatment of a disease such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof.

Heparin prodrugs and drug delivery stents formed therefrom

A method including introducing into a blood stream a delipidated high density lipoprotein (HDL) and a bioactive agent. A composition including a delipidated high density lipoprotein (HDL) and an auxiliary agent in a form suitable for delivery into a blood vessel. A composition including Apo A1 comprising a hydrophobic ligand suitable to interact with cell surface binding sites. A composition including Apo A1 and an agent selected to one of increase the ATP-binding cassette protein 1 (ABCA1) transporter expression in macrophages and protect ABCA1 from thiol-mediated degradation.

Lipid therapy

Growing community of inventors

Fremont, CA, United States of America

Syed Faiyaz Ahmed Hossainy