Advanced Cardiovascular Systems, Inc.

Abbott Cardiovascular Systems, Inc.

University of Texas System

Novocell, Inc.

Advanced Cardiocasvular Systems, Inc.

Syed F A Hossainy

Stephen D Pacetti

Yiwen Tang

Daryush Mirzaee

Lothar W Kleiner

Mikael Trollsas

Eugene T Michal

Steven Z Wu

Vinayak Bhat

David C Gale

Deborra Sanders Millare

Ni Ding

Evgenia Mandrusov

Fuh-Wei Tang

Judy A Guruwaiya

Wouter Erik Roorda

Thierry Glauser

Dariush Davalian

Florian Ludwig

Yung-Ming Chen

Li Fu Chen

Paul M Consigny

Gordon S Stewart

Keith Edward Fong

Andrew C Tung

Ty T Hu

Kurt W Scheinpflug

Deborra Sanders-Millare

Charles David Claude

Srinivasan Sridharan

Ashok A Shah

O Mikael Trollsas

Neil P Desai

Jeffrey Alan Hubbell

Amarpreet S Sawhney

Chandrashekhar Prabhakar Pathak

Michael H Ngo

Daniel A Castro

Benjamyn Serna

Jessica R DesNoyer

Shamim M Malik

Gina Zhang

Dorie M Happ

Yunbing Wang

Jason Van Sciver

Manish Gada

Jinping Wan

Orlando M Padilla

Sameer Harish

Florian Niklas Ludwig

Kevin L Woolbright

Jeff Royal

Bin Huang

John Joseph Stankus

Klaus Kleine

Fozan El-Nounou

Katsuyuki Murase

Arthur J Wen

Dorrie M Happ

Charles W Snyder

Anh Tran

David J Sherman

Carol Lee

Arkady Kokish

Florencia Lim

James Oberhauser

Irina Astafieva

Jeffrey A Steward

Richard Rapoza

Jessica Reneé DesNoyer

Jennifer L Hill

Li Zhao

Bjorn G Svensson

Andrew F McNiven

Debbie Sanders-Millare

Jacqueline Ghio

Mark A Williams

Ronald W Heil, Jr

Qi S Wang

Santosh V Prabhu

Sean A McNiven

Houdin Dehnad

Anthony S Andreacchi

Murthy V Simhambhatla

Vincent J Gueriguian

James M Jacobs

Boris Anukhin

Debashis Dutta

Christopher Feezor

Stephen R Dugan

Steven B Choi

Jeffrey T Ellis

Thomas David Esbeck

Rachel Bright

Gene Park

Hao-Ming Hsiao

Yuet Mei Khong

Steven L Mouw

Hong Ma

Nancy Kirsten

A method of treating vascular disease in a patient is disclosed that comprises deploying a bioabsorbable polymer scaffold composed of a plurality of struts at a stenotic segment of an artery of a patient, wherein after the scaffold supports the segment at an increased diameter for a period of time the polymer degrades and is progressively replaced by de novo formation of malleable provisional matrix comprising proteoglycan, wherein as the scaffold becomes more malleable and becomes disconnected as it degrades, wherein following coverage of the struts by a neointima layer and loss of mechanical support provided by the scaffold, the scaffold is pulled outward by positive remodeling of the vessel wall of the scaffolded segment.

Assessment of a drug eluting bioresorbable vascular scaffold

Methods of fabricating a polymer scaffold with increased radial strength including steps of elongation or strain of a biaxially oriented tube and annealing or thermal processing of the strained tube at a constant strain are disclosed. The steps of elongation and thermal processing increase axial direction chain orientation and lamellar crystal growth, increase radial strength, and decrease the thickness of the tube. The method allows fabrication of a scaffold with thinner struts which provide sufficient radial strength.

Method to increase radial strength of a bioresorbable scaffold

The present invention provides an absorbable coating for an implantable device and the methods of making and using the same.

Absorbable coating for implantable device

The present disclosure teaches methods of controlling the release rate of agents from a polymeric matrix. The methods relate to the application of pressure, and optionally, in combination with heat, to a polymeric coating.

Methods of treatment of polymeric coatings for control of agent release rates

Stents fabricated from polymer composites toughened by a dispersed phase are disclosed.

Stent fabricated from polymer composite toughened by a dispersed phase

Embodiments of the present invention include methods of treating, preventing, and/or ameliorating a vascular disease and/or disorder in a diabetic or pre-diabetic patient. The methods include implanting a stent in a vascular region in a diabetic or pre-diabetic patient, and prior to and/or during the implantation procedure, delivering a lubricant formulation to the vascular region. The stent may be a bare metal stent, or a drug eluting stent, such as a metal stent with a coating including a drug, such as everolimus or sirolimus.

Treatment of diabetic patients with a stent and locally administered adjunctive therapy

The present invention provides an implantable device having a coating including a slow dissolving polymer or material and the methods of making and using the same.

Implantable device with a triblock polymer coating

Embodiments of the present invention encompass methods of forming coatings, particularly coatings for medical devices, and more particularly, for braided or woven medical devices. Embodiments of the present invention encompass the coatings and the coated devices. The coatings may include a polymer and optionally a therapeutic agent.

Coatings for braided medical devices and methods of forming same

Methods of making polymeric devices, such as stents, with one or more modifications such as addition of plasticizers, to improve processing, and the devices made by these methods.

Plasticizers for a biodegradable scaffolding and methods of forming same

Methods of treating a diseased blood vessel exhibiting stenosis with a bioabsorable stent are disclosed. The implanted stent supports the section of the vessel at an increased diameter for a period of time to allow the vessel to heal. The stent loses radial strength sufficient to support the section of the vessel in less than 6 months after implantation, loses mechanical integrity, and then erodes away from the section. The biodegradable stent results in changes in properties of plaque with time as the stent degrades. The time-dependent properties include the luminal area of the plaque and plaque geometric morphology parameters.

Bioabsorbable stent that modulates plaque geometric morphology and chemical composition

An implantable medical device is disclosed having a helical construct including a set of spiral coils for local in vivo application of a therapeutic substance in a biological lumen. The helical construct is configured to apply less than 0.75 Bar of pressure to the biological lumen wall. The helical construct can have at least two sets of spiral coils having opposing helical directions. The device can be used for the treatment of vascular disorders such as restenosis and vulnerable plaque.

Drug delivery spiral coil construct

Nano-constructs comprising nanoshells and methods of using the nano-constructs for treating or ameliorating a medical condition are provided.

Nanoshells on polymers

Coatings for an implantable medical device and a method of fabricating thereof are disclosed, the coatings comprising polymers of lactic acid.

Coatings for implantable devices comprising polymers of lactic acid and methods for fabricating the same

Growing community of inventors

Fremont, CA, United States of America

Syed F A Hossainy