University of Missouri

Syed Barizuddin

Shubhra Gangopadhyay

Keshab Gangopadhyay

Sheila Ann Grant

Aaron Wood

Rajesh Shende

Sangho Bok

Rajagopalan Thiruvengadathan

Steven J Apperson

Cherian Joseph Mathai

Daniel Tappmeyer

Andrey Bezmelnytsin

Bhusban Mehendale

The invention broadly relates techniques for imaging and medical diagnosis and, more particularly, to the fabrication of flexible plasmonic gratings and the use thereof in detection of biomarkers. A first aspect of the invention provides for techniques for the fabrication of novel, flexible plasmonic gratings that can be inexpensively fabricated onto fiber optic cables, flexible films and substrates with non-uniform surfaces to enhance the imaging resolution. A second aspect of the invention provides for an ultra&#xac;high sensitivity (single molecule counting) biomarker detection platform useable for medical diagnosis based on a fluorescent sandwich ELISA assay performed on a plasmonic grating platform incorporated with a fluorescence detection unit.

Detection of biomarkers using plasmonic gratings

The invention provides homogeneous mesoporous metal oxide nanoenergetic composites. A composite of the invention has a regular and uniform nanostructure of metal oxide, which is structured by a surfactant. Metal fuel nanoparticles are homogenously distributed through the regular and uniform nanostructure. The invention further provides methods for making homogeneous metal oxide nanoenergetic composites. A method of the invention forms a metal oxide nanostructure via a sol-gel process with surfactant templating. Metal nanoparticles into the metal oxide nanostructure via wet impregnation.

Homogeneous mesoporous nanoenergetic metal oxide composites and fabrication thereof

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Columbia, MO, United States of America

Syed Barizuddin