Taiwanj Pharmaceuticals Co., Ltd.

Syaulan S Yang

Yan-Feng Jiang

Kuang Yuan Lee

Chiung Wen Wang

Sheng Hung Liu

Yu-Shiou Fan

Meng Hsien Liu

Chia-Hao Chang

Meng-Hsien Liu

Ting-ni Huang

Mei-chi Hsu

Chi-Han Chen

Hao Shiuan Liu

Meng-hsien Liu

Ying-chu Shih

Yan-feng Jiang

The compounds represented by Formula (I), which are peripheral alkyl and alkenyl chains extended benzene derivatives, are useful as dual autotaxin (ATX)/histone deacetylase (HD AC) inhibitors. These compounds may be included in a pharmaceutical composition along with a pharmaceutically acceptable carrier, and be used in a therapeutically effective amount for prophylaxis or treatment of various diseases and disorders.

Peripheral alkyl and alkenyl chains extended benzene derivatives and pharmaceutical composition including the same

The present disclosure relates to a compound of Formula I, or a geometric isomer, enantiomer, diastereomer, racemate, atropisomer, pharmaceutically acceptable salt, prodrug or solvate thereof. The present disclosure further relates to a composition comprising the compound of Formula (I). The compound and the composition described herein can be used to inhibit NADPH oxidase activity. 

NADPH oxidase inhibitors, pharmaceutical composition comprising the same, and application thereof

A novel structure of an opioid antagonist is provided. One of the exemplary compounds of the present disclosure has the structure of Formula (II). The present disclosure overcomes the discomfort of conventional opioid antagonist due to rapid absorption and improves the patient compliance thereof. 

Prodrugs of Naltrexone, Nalmefene and derivatives thereof

The present disclosure provides a benzene fused heterocyclic derivative of Formula (I):is a single or double bond; n is an integer of 0 or 1; A is &#x2014;CH&#x2014;, &#x2014;CH(OH)&#x2014;, or &#x2014;C(O)&#x2014;; G is C or N; X is &#x2014;CH&#x2014;, O, or &#x2014;C(O)&#x2014;; Y is alkyl, aryl, or heterocyclic alkyl optionally substituted with at least one substituent independently selected from a group consisting of: H, halogen, alkyl, alkyl substituted with at least one halogen, aryl, aryl substituted with at least one halogen, &#x2014;NRR, &#x2014;OR, &#x2014;RC(O)R, &#x2014;C(O)R, &#x2014;C(O)OR, &#x2014;C(O)ORRy3, &#x2014;NRC(O)R, &#x2014;NRC(O)NRR, &#x2014;NRC(O)ORR, &#x2014;NRC(O)ROR, C(O)NR(RR), &#x2014;C(O)NR(ROR), &#x2014;ORR, and &#x2014;OROR, wherein each of Rand Ris independently selected from a group consisting of H, oxygen, alkyl, and aryl, and Ris aryl optionally substituted with at least one halogen; Z is &#x2014;NRR, &#x2014;NRR, &#x2014;OR, &#x2014;ORR, &#x2014;C(O)RR, &#x2014;C(O)ORR, &#x2014;NRC(O)RR, &#x2014;NRC(O)ORR, &#x2014;C(O)NRR, or OROR, wherein each of Rand Ris independently selected from a group consisting of H, oxygen, alkyl and aryl, and Ris aryl optionally substituted with at least one substituent independently selected from a group consisting of halogen, OH, &#x2014;RCOOR, &#x2014;ORCOOR, &#x2014;RSOR, &#x2014;RSONRRR, &#x2014;RC(O)RR, &#x2014;RC(O)NRRR, &#x2014;RZC(O)NRSOR, wherein Rza is nil or alkyl, Ris H or alkyl, each of Rand Ris independently selected from a group consisting of H, OH, alkyl, aryl, alkoxyl, or NRRis a nitrogen-containing heterocyclic alkyl ring, Ris nil or a sulfonyl alkyl group. 

Benzene fused heterocyclic derivative and pharmaceutical composition comprising the same

Growing community of inventors

Zhubei, Taiwan

Syaulan S Yang