Vedabio, Inc.

Swetha Murali

Anurup Ganguli

Andrew Garst

Ketki Sawant

Ravi Vijayendran

Joshua Miller

Robert Plasschaert

The present disclosure relates to compositions of matter and methods used to activate effector nucleic acids and effector targets in vivo via a CRISPR-based cascade system. The compositions and methods achieve non-specific delivery of cascade system components to cells yet the cascade system works in a cell-specific manner.

Delivery of therapeutics in vivo via a CRISPR-based cascade system

The present disclosure relates to compositions of matter and assay methods used to detect one or more non-nucleic acid targets of interest in a sample. The compositions and methods provide signal boost upon detection of non-nucleic acid targets of interest in less than one minute and in some instances instantaneously at ambient temperatures down to 25° C. or less, allow for massive multiplexing, high accuracy, minimal non-specific signal generation, and are easily reprogrammable.

Detection of nucleic acid and non-nucleic acid target molecules

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San Diego, CA, United States of America

Swetha Murali