Global Life Sciences Solutions USA LLC

Cytiva Sweden Ab

General Electric Company

Swapnil Puranik

Manoj Kumar Ramakrishna

Klaus Gebauer

Prashanth Hosabettu Mohan

Sandip Maity

Nagapriya Kavoori Sethumadhavan

Andreas Castan

Haresh Digambar Patil

Anoop Bhargav

Praveen Paul

Sebastian John

Mohammed Mehtab Khan

Hanish Lakhani

Nagaraju Konduru

Sameera Simha Hindupur

Hemalatha J

Li Ou

Nishu Garg

The present invention relates to a computer implemented method for determining a weld integrity test result performed by a system configured to aseptically transferring cells to a container (BR), the method comprising welding () a vial to a connector to obtain a fluid-tight seal between the vial (V) and a connector (C), the connector being provided with a pair of conduits each having one end protruding through the connector and into the vial, sealing () an opposite end of one of the conduits, generating () a fluid pressure different to an ambient fluid pressure at an opposite end of the other conduit, measuring () a fluid pressure within at least one of the conduits, determining () a fluid pressure change based on the ambient pressure and the measured fluid pressure, determining () the weld integrity test result as pass or as fail based on the fluid pressure change.

Method for determining a weld integrity test result

Methods for selecting a filter for a filtration process are described. Input data is received, and based on the input data, one or more filter characteristics for each of a plurality of filter candidates for a filtration process are identified. Process parameters of the filtration process are identified. A computer-implemented simulation process of the filtration process for each of the plurality of filter candidates is performed, based on the identified process parameters and identified filter characteristics. One or more output characteristics of the filtration process are determined based on the simulation. A filter candidate of the plurality of filter candidates is selected based on the one or more output characteristics.

Method, apparatus, system and computer program product for selecting a filter for a filtration process

A microfluidic device () is disclosed for in-process monitoring of cell culture conditions including for example one or more of: cell density; cell viability; secreted proteins; protein analysis; epitope markers; concentrations of metabolites or nutrients and antigenic determinations; the device comprising: a cell inlet path (); plural fluid reservoirs () in fluid communication with the cell input path, a cell analysis area () in fluid communication with the path and reservoirs, and a waste storage volume () also in fluid communication with the cell analysis area, the device being operable to cause a primary fluid flow along the inlet path to the analysis area, and to selectively cause secondary fluid flow(s) into the path from none, one or more of the selected reservoirs to combine, if one or more of the reservoirs are selected, with the primary fluid flow from the cell inlet path, in each case for analysis at the cell analysis area, the device being further operable to cause a fluid flow of the primary and any combined secondary flows from the cell analysis area into the waste storage volume.

Microfluidic device for cell culture monitoring

The present invention relates to a novel bioreactor system for cell cultivation. More specifically, the invention relates to a compact bioreactor system which has several integrated functions and enables small scale static culture as well as scale-up rocking culture in the same bioreactor. The bioreactor system comprises tray for positioning of a cell culture bag having adjustable volume, a lid covering the cell culture bag and provided with heating function, an integrated perfusion unit, an integrated cell loading unit, and an integrated unit for automatic cell culture sampling, wherein the bioreactor system is controlled by a single control unit. The invention also relates to a method of cell culture using the bioreactor system for culture of therapeutic cells.

Bioreactor system for cell cultivation

Growing community of inventors

Bengaluru, India

Swapnil Puranik