Emcure Pharmaceuticals Limited

Lupin, Inc.

Swapnil Panditrao Sonawane

Mukund Keshav Gurjar

Samit Satish Mehta

Golakchandra Sudarshan Maikap

Gulabrao Dagadu Patil

Shivnath Bhaupatil Shinde

Pankaj Shalikrao

Rajendra Dagesing Mahale

Milind Gharpure

Pankaj S Patil

Srihari Shivaji Mane

Pankaj Shalikrao Patil

Pankaj Shallkrao Patil

The present invention relates to a novel synthetic route for the preparation of raltegravir and pharmaceutically acceptable salts, starting from 2-amino-2-methylpropanenitrile and oxadiazole carbonyl chloride, through the formation of a pyrimidinone intermediate of formula (V).

Synthesis of Raltegravir

Synthesis of raltegravir

The present disclosure relates to processes for the preparation of taxane derivatives with improved purity and enhanced stability. The taxane derivatives prepared according to the processes described herein are useful for the preparation of pharmaceutical compositions.

Process for preparation of taxane derivatives

A process for preparation of 4-hydroxy-pyran-2-one derivative of formula (I), wherein R is, and wherein Rand Rare methyl and Ris hydrogen or methyl, wherein R is as defined before, and Ris hydrogen, NHor an alkali metal,

Method for manufacture of 4-hydroxy pyran-2-one derivatives

Growing community of inventors

Pune, India

Swapnil Panditrao Sonawane