Other

Svetlana V Shelyazhenko

Jury A Fialkov

Gunar Y Dubur

Lev Moiseevich Yagupolsky

Agris A Kimenis

Rasma O Vitolin

Valeria V Kastron

A process for preparing difluoromethoxy derivatives of aromatic aldehydes having a common formula ##STR1## where Z is H,H; or n is a whole number of 1 and 2. The above process comprises the reaction between oxy derivatives of aromatic aldehydes selected from the group consisting of monooxy derivatives of aromatic aldehydes, and difluorochloromethane which reaction is carried out in an aqueous-dioxane medium at a temperature of 60.degree. to 70.degree. C., in the presence of 6 to 10 moles of caustic alkali per 1 mole of a starting oxyaldehyde.

Process for preparing difluoromethoxy derivatives of aromatic aldehydes

The present invention relates to derivatives of 1,4-dihydropyridine and, more specifically, to 2,6-dimethyl-3,5-dimethoxycarbonyl-4-(o-difluoromethoxyphenyl)-1,4-dihydro pyridine of the formula: ##STR1## This compound features a clearly pronounced hypotensive activity while being low-toxic, wherefore it can be used in medicine for treating hypertensive disease.

2,6-Dimethyl-3,5-dimethoxycarbonyl-4-(ortho-difluoromethoxyphenyl)-1,4-di

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Kyiv, Ukraine

Svetlana V Shelyazhenko