Astra Lakemedel Aktiebolag

Aktiebolaget Astra

Astra Lakemedel Akteibolag

Sven O Gren

Svante Bertil Ross

Seth-Olov Thorberg

Ulf H Lindberg

Thomas Hogberg

Sten I Ramsby

Lars George Johansson

Tomas De Paulis

Gosta L Florvall

Karl S Bengtsson

Hans E Strom

Tomas DePaulis

Jan O Lundstrom

Gerd M Hallnemo

Marianne E Widman

Bengt C Ulff

Ulf M Lindberg

Novel therapeutically active compounds of the formula ##STR1## wherein Z.sup.i, being Z.sup.1, Z.sup.2 or Z.sup.3, is the same or different and selected among OH, OR.sup.1, NH.sub.2, NR.sub.2.sup.4, NHR.sup.4, SH, SR.sup.4 and OR.sup.4 wherein R.sup.1 is a formyl group, an acyl group, an alkoxycarbonyl group or a mono- or dialkylcarbamoyl group and R.sup.4 is a lower alkyl group,

Oxysalicylamido derivatives

Aralkyl esters and processes for their preparation

Novel therapeutically active compounds of the formula ##STR1## wherein R is a straight or branched alkyl group with 6-18 carbon atoms, R.sup.1 is hydrogen, chlorine, bromine or an alkyl group with 1-3 carbon atoms and R.sup.2 is chlorine, bromine or an alkyl group with 1-3 carbon atoms; or a physiologically acceptable salt or an optical isomer thereof, methods and intermediates for their preparation, pharmaceutical preparations containing them and methods for their therapeutical use.

Benzamido-derivatives

Novel therapeutically active compounds of the formula ##STR1## wherein R.sup.1 and R.sup.2 are the same or different and each represents a hydrogen atom, a halogen atom, a cyano group, a lower alkyl group or an acyl group, R.sup.3 is a lower alkyl group; an alkenyl group; or a benzyl group optionally substituted with fluorine, chlorine, bromine, trifluoromethyl, lower alkyl or lower alkoxy, A.sup.1 and A.sup.2 are the same or different and each represents a hydrogen atom, a lower alkyl group, an acyl group, an alkoxycarbonyl group or a dialkylcarbamyl group, provided that when A.sup.1 and A.sup.2 are the same lower alkyl group and R.sup.3 is ethyl, R.sup.1 or R.sup.2 or both are selected among cyano, lower alkyl and acyl; or a physiologically acceptable salt or optical isomers thereof, methods for their preparation, pharmaceutical preparations containing the compounds and methods for their therapeutical use.

A compound of the general formula ##STR1## and pharmaceutically acceptable salts thereof, in which formula the groups R.sup.0 are the same or different and are selected from the group consisting of hydrogen, halogen, alkyl having 1, 2 or 3 carbon atoms, and alkoxy having 1, 2 or 3 carbon atoms; R.sup.1 and R.sup.2 are methyl; R.sup.3 and R.sup.4 are the same or different and are hydrogen or an alkyl group having 1, 2 or 3 carbon atoms; and n is 0. Pharmaceutical preparations containing these compounds are useful for treatment of depressive disorders.

Compounds having antidepressive activity

A compound of the general formula ##STR1## and pharmaceutically acceptable salts thereof, in which formula the groups R.sup.o are the same or different and are selected from the group consisting of hydrogen, halogen, alkyl having 1, 2 or 3 carbon atoms, and alkoxy having 1, 2 or 3 carbon atoms; R.sup.1 is hydrogen, methyl or ethyl; R.sup.2 is methyl or ethyl; R.sup.3 and R.sup.4 are the same or different and are hydrogen or an alkyl group having 1, 2 or 3 carbon atoms; and n is 0, 1 or 2. Pharmaceutical preparations containing these compounds are useful for treatment of depressive disorders.

2-Methyl-1-(substituted)phenyl-2-propyl esters of 2-aminopropanoic acid

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Nykvarn, Sweden

Sven O Gren