Sloan-kettering Institute for Cancer Research

Sven Nelander

Björn Nilsson

Wei Wang

Peter Gennemark

Chris Sander

Techniques for modeling living biological systems include receiving constant values for multiple interaction factors w. A set of initial state values is received for state variables that indicate relevant properties of a living biological system. Also received is a set of trial values for perturbation variables that indicate factors that might affect one or more of the relevant properties of the biological system. A temporal change in a value for a particular state variable is determined based on a non-linear transformation of a sum of the trial value for the perturbation that affects the particular state added to a sum of all non-zero values for a product of wand a state variable over all state variables. In some embodiments, measurement-based values are received for a measurable subset of the state variables. Values for the constant interaction factors ware determined based on the measurement-based values.

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Gothenburg, Sweden

Sven Nelander