Novo Nordisk A/s

Novozymes A/s

Other

Unilever Plc

Novo Nordisk Biotech, Inc.

Sven Hastrup

Sven Branner

Dorrit A Aaslyng

Ole Hvilsted Olsen

Johan Haverkamp

Maarten Robert Egmond

Fanny Norris

Carsten Mailand Hjort

Villy Johannes Jensen

Eric Casteleijn

Fred Hagen

Merete Simonsen

Helle Fabricius Woldike

John David Marugg

Arnoldus Theodorus Anthonius Mooren

Leif N&oslash;rskov-Lauridsen

Henning Thoegersen

Wouter Musters

Kristian Sass-Oerum

Poul Lindegaard

Sebastian Beck Joergensen

Allan Christian Shaw

Nina Eriksen

Kim Vilbour Andersen

Charlotte Helgstrand

Jakob De Vlieg

Steffen Bjorn Petersen

Steffen Bj&oslash;rn Petersen

Leif N&oslash;rskov-Lauritsen

Martin Schulein

Shamkant Anant Patkar

Claus Crone Fuglsang

Grethe Norskov Rasmussen

Jeffrey R Shuster

Lars Thim

Donna L Moyer

Tove Christensen

John D Marugg

Leif No slashedrskov-Lauritsen

Mark Madden

Jan Mo Mikkelsen

Michael Paolo Bastner Sandrini

Helle Fabricius W&ouml;ldike

Martin Edward Judge

Leif Norskov-Lauritsen

Peter Kristensen

Eric Castelijn

Birthe Ravn Jo Slashedrgensen

Birgitte Bojer Jo Slashedrgensen

Leif Norskov-Lauridsen

Arnoldus Theodorus Mooren

Michael P Bastner Sandrini

Leif No slashedrskov-Lauridsen

Steffen Bjo Petersen

Kennet Christiansen

The invention relates to MIC-1 fusion proteins. More specifically it relates to compounds comprising fusion proteins comprising a MIC-1 protein or an analog thereof at the C-terminus of the fusion protein and a functional variant of human serum albumin at the N-terminus of the fusion protein connected via a peptide linker. The compounds of the invention have MIC-1 activity. The invention also relates to pharmaceutical compositions comprising such compounds and pharmaceutically acceptable excipients, as well as the medical use of the compounds.

MIC-1 fusion proteins and uses thereof

The present invention relates to enzymes produced by mutating the genes for a number of subtilisin proteases and expressing the mutated genes in suitable hosts are presented. The enzymes exhibit improved wash performance in comparison to their wild type parent enzymes. The enzymes are well-suited for use in detergent compositions.

Modified subtilisins and detergent, compositions containing same

The present invention relates to mutations of a subtilisin gene which result in changes in the chemical characteristics of subtilisin enzymes. Mutations at specific nucleic acids of the subtilisin gene result in amino acid substitutions and consequently, altered enzyme function. Some of these mutant enzymes exhibit physical properties advantageous to industrial applications, particularly in the detergent industry, providing subtilisin which is more stable to oxidation, possesses greater protease activity, and exhibits improved washability.

Useful mutations of bacterial alkaline protease

Modified subtilisins and detergent compositions containing same

The present invention relates to mutations of the subtilisin gene, some of which result in changes in the chemical characteristics of subtilisin enzyme. Mutations are created at specific nucleic acids of the subtilisin gene and, in various specific embodiments, the mutant enzymes possess altered chemical properties including, but not limited to, increased stability to oxidation, augmented proteolytic activity, and improved washability. The present invention also relates, but is not limited to, the amino acid and DNA sequences for two proteases derived from variants, subtilisin 147 and subtilisin 309, as well as mutations of these genes and the corresponding mutant enzymes.

The present invention relates to a polypeptide with appetite regulating function/activity, a nucleic acid construct encoding the polypeptide and a method of producing the polypeptide. The invention further relates to recombinant vectors comprising the nucleic acid construct encoding the polypeptide, recombinant host cells comprising the nucleic acid construct or the recombinant vector.

Polypeptide with appetite regulating activity

The present invention relates to cellulase preparations consisting essentially of a homogeneous endoglucanase component. The cellulase preparation may be employed in the treatment of cellulose-containing fabrics for harshness reduction, for color clarification, or to provide a localized variation in the color of such fabrics, or in the treatment of paper pulp.

Cellulase preparation comprising an endoglucanase enzyme

The invention relates to a method of producing an extracellular protein in a bacterium provided with an inner and an outer cell membrane, the method comprising: (a) providing a recombinant vector including a DNA construct comprising a DNA sequence encoding the prepropeptide or part of the prepropeptide of a bacterial extracellular protease selected from the group consisting of,protease I, Bacillus metalloproteases and Bacillus serine proteases preceding and operably connected to a DNA sequence encoding a desired protein, (b) transforming cells of a microorganism provided with an inner and outer cell membrane with the recombinant vector of step (a), (c) culturing the transformed cells of step (b) under conditions permitting expression of said DNA insert and leakage of the bacterial extracellular protease propeptide fused to the desired protein into the culture medium, and (d) recovering the resulting protein from the medium.

Process for producing extracellular proteins in bacteria

A cellulase preparation consisting essentially of a homogeneous endoglucanase component which is immunoreactive with an antibody raised against a highly purified .about.43 kD endoglucanase derived from Humicola insolens, DSM 1800, or which is homogeneous to said .about.43 kD endoglucanase, may be employed in the treatment cellulose-containing fabrics for harshness reduction or color clarification or to provide a localized variation in the color of such fabrics, or it may be employed in the treatment of paper pulp.

The present invention relates to isolated and purified cellulose- or hemicellulose-degrading enzymes, comprising a catalytically active domain, a carbohydrate binding domain and a linking B region which operably links the catalytically active domain and the carbohydrate binding domain, wherein the carbohydrate binding domain has the following core sequence: ##STR1## wherein the enzyme is endogenous to a strain of a fungus other than Trichoderma or Phanerochaete.

Enzyme capable of degrading cellulose or hemicellulose

The present invention relates to mutations of the subtilisin gene, some of which result in changes in the chemical characteristics of subtilisin enzyme. Mutations are created at specific nucleic acids of the subtilisin gene and, in various specific embodiments, the mutant enzymes possess altered chemical properties including, but not limited to, increased stability to oxidation, augmented proteolytic activity, and improved washability. The present invention also relates, but is not limited to, the amino acid and DNA sequences for two proteases derived from Bacillus lentus variants, subtilisin 147 and subtilisin 309, as well as mutations of these genes and the corresponding mutant enzymes.

Growing community of inventors

Copenhagen, Denmark

Sven Hastrup