Georgia Tech Research Corporation

Joslin Diabetes Center, Inc.

The Beth Israel Hospital Association

Sven-Erik Bursell

Mark A Samuels

Jonathan A Eppstein

Scott W Patterson

Nai T Yu

Joseph L Zelvin

Juan R Serur

Lloyd M Aiello

William Kelley Gardner

A retinal imaging system includes a light source and optics which receive light from the light source and which transmit the light to produce a beam that is substantially convergent. The beam penetrates a lens of an eye and diverges following penetration of the lens to illuminate an area of a retina of the eye. An imaging device receives a reflection of light from the retina.

Retinal imaging system

An image acquisition unit provides true color high resolution digital images of the retina of the eye to a computer network (14, 16, 18) which interfaces with a central record library and displays the images at a remote work station (20A and 20B) for diagnostic examination. The computer network (14, 16, 18) is also interfaced with a unit for entering medical history information, and the diagnostic data, stereo images and medical records are linked in a relational database allowing all text and image records of the patient to reside on a work station/display (20A and 20B) for review or consultation. A telecommunications link (22) interconnects the computer network and image examination stations with the image acquisition station where the patient is actually examined, so that stereo fundus images may be made available through the computer without degradation for viewing on the examination displays remotely from the room, building, or city where the images are acquired from the patient. By introducing digital true-color normalization at the image acquisition source (34,32), applicant avoids the problem of spurious color artifacts arising when the images are viewed subsequently, or on other monitors.

Stereoscopic imaging system for retinal examination with remote

Apparatus and methods for characterizing biological tissues and other turbid media with normalization that serves to compensate for the effects of scattering, reflectance, and absorption are disclosed.

Apparatus and methods for measuring characteristics of biological

Apparatus and methods for noninvasively diagnosing diabetes mellitus, the prediabetic condition, and cataracts in the human (or other) body are disclosed. Diagnoses are made by illuminating ocular lens tissue with a narrow-band light source at a selected wavelength, detecting the backscattered radiation intensity at the peak of the fluorescent response, and normalizing the detected value with the intensity of its Rayleigh component. Measurements provided in this manner can be used as improved indicators of the presence or absence of certain diseases or conditions.

Apparatus and methods for quantitatively measuring molecular changes in

A method to determine the cholesterol level in a patient in a non-invasive manner by delivering a beam of light to a patient's eye. The intensity of light scattered from the aqueous of the eye and the mobility of the protein scatterers in the eye are measured and compared to a control. An apparatus to detect the cholesterol level in a patient in a non-invasive manner which delivers a beam of light to a patient's eye, collects the scattered light from the patient's eye and correlates the scattered light to a cholesterol level measurement.

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Newton, MA, United States of America

Sven-Erik Bursell