Aktiebolaget Hassle

Sven E Sjostrand

Ulf K Junggren

Arne E Brandstrom

Stig Ake Carlsson

Enar I Carlsson

Peder Bernhard Berntsson

Gert C Strandlund

Lars Ek

Benny Roger Samuelsson

Bengt A Ablad

The present invention relates to novel compounds of the formula ##STR1## wherein R.sup.1 and R.sup.2 are the same or different and are each hydrogen, alkyl, halogen, carbomethoxy, carbethoxy, alkoxy, or alkanoyl, R.sup.6 is hydrogen, methyl or ethyl, R.sup.3, R.sup.4 and R.sup.5 are the same or different and are each hydrogen, methyl, methoxy, ethoxy, methoxyethoxy or ethoxyethoxy whereby R.sup.3, R.sup.4 and R.sup.5 are not all hydrogen, and whereby when two of R.sup.3, R.sup.4 and R.sup.5 are hydrogen the third of R.sup.3, R.sup.4 and R.sup.5 is not methyl. The compounds are potent gastric acid secretion inhibitors.

Substituted 2-(-benzimidazolyl)pyridines

Gastric acid secretion inhibiting substituted

Ortho-para-substituted phenoxy-hydroxypropylamines having the general formula ##STR1## and pharmaceutically acceptable, non-toxic acid addition salts thereof, wherein R.sup.1 is alkyl or hydroxyalkyl, R.sup.2 is alkoxyalkyl or alkylthioalkyl, and R.sup.3 is halogen, alkyl, alkenyl, alkinyl, alkoxymethyl, or alkoxy are disclosed, as are methods for their preparation. Pharmaceutical preparations are prepared whose active ingredients include at least one of the newly discovered phenoxy-hydroxypropylamine compounds. Therapeutically effective doses of these preparations selectively block the .beta.-receptors of the heart making them useful in treating heart diseases in animals including humans.

Phenoxy-hydroxypropylamines, their preparation, and method and

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Kungsbacka, Sweden

Sven E Sjostrand