Astra Lakemedel Aktiebolag

Sven Bengt Akerman

Ulf H Lindberg

Rune V Sandberg

A compound of the formula ##STR1## and pharmaceutically acceptable acid addition salts thereof, in which R.sub.1 represents an alkyl group selected from n-propyl, i-propyl, n-butyl, i-butyl and sek.butyl, R.sub.2 and R.sub.3 are the same or different and represent an alkyl group selected from ethyl, n-propyl, and i-propyl, or R.sub.2 and R.sub.3 together with the nitrogen atom may form a pyrrolidine or piperidine ring, and n is 2 or 3. Pharmaceutical preparations containing these compounds are useful as local anesthetics.

Local anesthetics tertiary aminoalkoxyphenyl ethers

A novel class of glycylglycine amides has been discovered having value as antiarrhythmic agents. The preferred compound of the present invention has the structural formula ##EQU1## Also included within the scope of this invention are compounds having C.sub.1 -C.sub.3 alkyl, alkoxy and halo substituents in the ortho, para or meta positions of the aromatic ring, compounds in which the phenyl group is replaced by benzyl or substituted benzyl and compounds in which the glycylglycine chain may be substituted with lower alkyl groups or may contain heterocyclic rings.

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Sodertalje, Sweden

Sven Bengt Akerman